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To report or not to report? Regulations win, despite the unavoidable nature of renovations

Lab Animal volume 49, pages 269–270 (2020)Cite this article

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This scenario is a great example of the growing pains felt by many institutions, as their units manage ongoing growth of both infrastructure and research programs—often in very close proximity to each other.

Upon initial review of the scenario, we were undecided on the necessity for reporting, given the volume of construction noise at the institution, combined with published data that show noise and vibration associated with large scale construction projects decrease reproductive efficiency in mouse colonies by decreasing live birth rates and increasing the number of stillborn pups.1,2 We questioned whether this issue is so prevalent and expected in a growing program that it could be considered an example of situations not normally required to be reported, as suggested in OLAW Notice NOT-OD-05-034: “death or failures of neonates to thrive when husbandry and veterinary medical oversight of dams and litters was appropriate.”3

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References

  1. Rasmussen, S., Glickman, G., Norinsky, R., Quimby, F. W. & Tolwani, R. J. J Am Assoc Lab Anim Sci. 48(4), 363–370 (2009).

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  2. Reynolds, R. P., Kinard, W. L., Degraff, J. J., Leverage, N. & Norton, J. N. J Am Assoc Lab Anim Sci. 49(5), 592–597 (2010).

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  3. National Institutes of Health. Guidance on Prompt Reporting to OLAW under the PHS Policy on Humane Care and Use of Laboratory Animals. Notice NOT-OD-05-034 (National Institutes of Health, Bethesda, MD, 24 February 2005). https://grants.nih.gov/grants/guide/notice-files/NOT-OD-05-034.htm

  4. U.S. Department of Health and Human Service. Public Health Service Policy on Humane Care and Use of Laboratory Animals (2015).

  5. ARENA and OLAW. Institutional Animal Care and Use Committee Guidebook 2nd edn. (OLAW, Bethesda, MD, 2002).

  6. Institute for Laboratory Animal Research. Guide for the Care and Use of Laboratory Animals 8th edn. (National Academies Press, Washington, DC, 2011).

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Authors and Affiliations

  1. Division of Comparative Medicine, University of North Carolina, Chapel Hill, NC, USA

    Emily Weston & Courtney Parnell Nesline

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  1. Emily Weston
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  2. Courtney Parnell Nesline
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Correspondence to Courtney Parnell Nesline.

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Weston, E., Nesline, C.P. To report or not to report? Regulations win, despite the unavoidable nature of renovations. Lab Anim 49, 269–270 (2020). https://doi.org/10.1038/s41684-020-0639-5

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