Regenerative potential of multipotent mesenchymal stromal cells from the human umbilical cord (MMSC-UC) in the suspension and spheroid form was revealed during the progression of experimental small focal myocardial infarction in rats. In isoproterenol-induced myocardial infarction, foci of necrosis and inflammatory infiltrate and at later terms fibrosis foci were found mainly in the left ventricle of rat heart. In rats receiving MMSC-UC, destructive changes in the myocardium, fibrous scars, and inflammatory process were less pronounced. MMSC-UC also contributed to normalization of the morphofunctional parameters of the heart. Spheroids exhibited higher efficiency in comparison with cell suspension.
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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 2, pp. 89-97, June, 2020
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Krasina, M.E., Kosheleva, N.V., Lipina, T.V. et al. Regenerative Potential of a Suspension and Spheroids of Multipotent Mesenchymal Stromal Cells from Human Umbilical Cord on the Model of Myocardial Infarction in Rats. Bull Exp Biol Med 169, 549–557 (2020). https://doi.org/10.1007/s10517-020-04928-0
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DOI: https://doi.org/10.1007/s10517-020-04928-0