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Medicinal Chemistry

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ISSN (Print): 1573-4064
ISSN (Online): 1875-6638

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New Approaches in Sensing and Targeting Bacterial rRNA A-site

Author(s): Preethi Parameswaran, Nihar Ranjan* and Swaran J.S. Flora*

Volume 17, Issue 4, 2021

Published on: 11 October, 2019

Page: [299 - 309] Pages: 11

DOI: 10.2174/1573406415666191011160035

Price: $65

Abstract

New chemical agents that could combat increasing antibiotic resistance are urgently needed. In this mini-review, an old but highly relevant RNA sequence which is crucial for the continuation of bacterial life-cycle is covered. Some of the most significant advances of the last decade in sensing and targeting the bacterial rRNA A-site: a well-validated binding site of proverbially known aminoglycoside antibiotics are described. Some of the major advances in direct sensing of the bacterial decoding side (A-site) are described and also new fluorescent molecules that are capable of detecting lead compounds through high-throughput assays by displacement of fluorescent probe molecules are highlighted. Lastly, some of the recently discovered non-aminoglycoside small molecule binders of bacterial rRNA A-site as a new class of molecules that could provide future scaffolds and molecules for developing new antibacterial agents have been discussed.

Keywords: A-site, rRNA, FRET, antimicrobial agents, drug discovery, antimicrobial agents, drug discovery, Mycobacterium tuberculosis.

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Graphical Abstract

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