Signal hotspot mutations in SARS-CoV-2 genomes evolve as the virus spreads and actively replicates in different parts of the world
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open access
Keywords
Severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2)
Sequence comparisons between 570 viral genomes to Wuhan isolate
Selection of viral hotspot mutations
Impact on replication-relevant viral proteins
Consequences for secondary and tertiary structures of viral RNA
Questions about immunogenesis and vaccine development
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© 2020 The Author(s). Published by Elsevier B.V.