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Nucleophilic substitution of the nitro group in 1-substituted 3-nitro-1H-1,2,4-triazoles in ethanolic potassium hydroxide

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Chemistry of Heterocyclic Compounds Aims and scope

Dehydrochlorination of 1-(2-chloroethyl)-3-nitro-1H-1,2,4-triazole in ethanolic potassium hydroxide is accompanied by nucleophilic substitution of the nitro group by the ethoxy group. The same nucleophilic exchange in 1-substituted 3-nitro-1H-1,2,4-triazoles occurs in methanol and n-propanol solutions of potassium hydroxide.

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The study was carried out at Russian-Armenian University at the expense of funds allocated within the framework of the subsidy of the Ministry of Education and Science of the Russian Federation to finance the research activities of Russian-Armenian University, as well as with the financial support of the State Committee on Science of the Ministry of Education and Science of the Republic of Armenia within the framework of scientific project No. 18T-2E151.

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Authors and Affiliations

  1. Institute of Organic Chemistry of Scientific–Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia, 26 Azatutyan Ave., 0014, Yerevan, Armenia

    Ani H. Hasratyan, Astkhik А. Sukoyan, Gevorg G. Danagulyan & Hovhannes S. Attaryan

  2. Molecular Structure Research Center of Scientific–Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia, 26 Azatutyan Ave., 0014, Yerevan, Armenia

    Aleksan G. Shakhatuni

  3. Russian-Armenian University, 123 Hovsep Emin St., 0051, Yerevan, Armenia

    Gevorg G. Danagulyan & Hovhannes S. Attaryan

Authors
  1. Ani H. Hasratyan
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  2. Astkhik А. Sukoyan
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  3. Aleksan G. Shakhatuni
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  4. Gevorg G. Danagulyan
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  5. Hovhannes S. Attaryan
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Correspondence to Ani H. Hasratyan.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2020, 56(8), 1100–1102

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Hasratyan, A.H., Sukoyan, A.А., Shakhatuni, A.G. et al. Nucleophilic substitution of the nitro group in 1-substituted 3-nitro-1H-1,2,4-triazoles in ethanolic potassium hydroxide. Chem Heterocycl Comp 56, 1100–1102 (2020). https://doi.org/10.1007/s10593-020-02780-8

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  • DOI: https://doi.org/10.1007/s10593-020-02780-8

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