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Polymeric Hydrogels for Controlled Insulin Release

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Abstract

On the example of published and new experimental data, it was shown that insulin-containing hydrogels based on copolymers of N-(2-D-glucose)acrylamide and acrylamide crosslinked by Concanavalin A can simulate one of the functions of the pancreas, i.e., they can secrete insulin upon an increase in the glucose concentration in the surrounding medium, including a two-stage mechanism with the maximum rate in the first stage.

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Funding

The work was carried out as part of the State assignment of the Topchiev Institute of Petrochemical Synthesis of the Russian Academy of Sciences.

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Authors and Affiliations

  1. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, 119991, Moscow, Russia

    I. L. Valuev, L. V. Vanchugova & L. I. Valuev

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  1. I. L. Valuev
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  2. L. V. Vanchugova
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  3. L. I. Valuev
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Correspondence to I. L. Valuev.

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Conflict of interests. The authors declare that they have no conflict of interest.

Statement on animal welfare. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

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Translated by G. Levit

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Valuev, I.L., Vanchugova, L.V. & Valuev, L.I. Polymeric Hydrogels for Controlled Insulin Release. Appl Biochem Microbiol 56, 505–511 (2020). https://doi.org/10.1134/S0003683820050154

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  • DOI: https://doi.org/10.1134/S0003683820050154

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