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First molecular identification of porcine circovirus-like agents in dogs and cats in China

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Abstract

Porcine circovirus-like agents comprise two types of viruses: porcine circovirus-like viruses (P1, P2, P3, and P4) and porcine circovirus-like mini agents (PCVL258, PCVL264, PCVL201, and PCVL347). Of these, P1 has been identified in pigs, cattle, goats, and rabbits in China; P2, P3, P4, PCVL258, and PCVL264 have been identified in pigs; and PCVL201 and PCVL347 have been identified in cattle. The purpose of this study was to determine whether dogs and cats have been exposed to porcine circovirus-like agents. We screened 158 serum samples from diseased dogs and 41 from cats in China by PCR and nucleotide sequencing. In dogs, approximately 18% (n = 28) were positive for P1, 17% (n = 26) for PCVL258, and 9% (n = 14) for PCVL264; in cats, 17.1% (n = 7) were positive for P1, 9.8% (n = 4) for P4, and 14.6% (n = 6) for PCVL258. The P1 genomes in this study consisted of 648 nucleotides (nt) and shared 96.8 to 100% nt identity with other P1 genomes in GenBank. The P4 genome shared 98.3 to 100% nt identity with other reported P4 genomes, and PCVL258 and PCVL264 showed 100% nt identity with previously reported genomes. To our knowledge, this is the first report on molecular characterization of porcine circovirus-like agents in dogs and cats. Further studies are needed to clarify the epidemiology, evolution, and pathogenesis of porcine circovirus-like agents in dogs and cats.

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Acknowledgements

This study was supported by grants from the National Natural Science Foundation of China (Grant Nos. 30972184, 31272574).

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Authors and Affiliations

  1. Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences,·Key Laboratory of Animal Diseases, Diagnostics, and Immunology, Ministry of Agriculture, Key Laboratory of Food Quality and Safety of Jiangsu Province-State Key Laboratory Breeding Base, Nanjing, China

    Libin Wen, Aihua Mao, Jianping Xie & Kongwang He

  2. Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infections Diseases and Zoonoses, Yangzhou, Jiangsu, China

    Libin Wen, Aihua Mao, Jianping Xie & Kongwang He

Authors
  1. Libin Wen
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  2. Aihua Mao
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  3. Jianping Xie
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  4. Kongwang He
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Contributions

LW conceived and designed the study and prepared the manuscript; AM and JX performed the experiments; KH reviewed and edited the manuscript. All authors read and approved the final manuscript.

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Correspondence to Libin Wen.

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The authors declare that they have no conflict of interest.

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All international, national, and institutional guidelines for the care of sampled animals were followed.

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Edited by William Dundon.

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Wen, L., Mao, A., Xie, J. et al. First molecular identification of porcine circovirus-like agents in dogs and cats in China. Virus Genes 56, 781–784 (2020). https://doi.org/10.1007/s11262-020-01796-8

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  • DOI: https://doi.org/10.1007/s11262-020-01796-8

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