Abstract
The present study considers effects of a lipid complex isolated from the aqueous–ethanol (70%) extract from the marine red alga Ahnfeltia tobuchiensis and effects of the Essentiale commercial preparation on the biochemical parameters of blood plasma and erythrocyte membranes of mice exposed to experimental stress (suspension by the scruff of the neck). The pharmacological effect of the lipid complex from A. tobuchiensis is manifested as elimination of dyslipidemia and hypercholesterolemia accompanied by a reduction in the levels of total lipids and low-density lipoproteins, an increase in the level of high-density lipoproteins in plasma, and normalization of the cholesterol/phospholipid ratio and the phospholipid composition of erythrocyte membranes. The Ahnfeltia extract was not inferior to the Essentiale reference preparation in terms of effectiveness and was even superior in the potential to restore the blood lipid composition and the phospholipid fraction ratio in erythrocyte membranes. The pharmacological effect of the lipid complex from Ahnfeltia is determined by the action of its phospholipid fractions and polyunsaturated n-6 and n-3 fatty acids, which contribute to the utilization of cholesterol from membranes and the enhancement of the lipoprotein ratio towards increase in high-density lipoproteins and are also involved in erythrocyte membrane repair.
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The study was carried out within the framework of the State Assignment on the topic no. 0271-2019-0004 The effect of natural and anthropogenic factors on biogeochemical processes and condition of biota in marine ecosystems (State registry no. AAAA-A17-117030110038-5).
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Statement on the welfare of animals. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed. The study was approved by the Ethics Commission at the Il’ichev Pacific Oceanological Institute, Far Eastern Branch, Russian Academy of Sciences (protocol no. 13 dated October 10, 2018).
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Kushnerova, N.F., Fomenko, S.E., Sprygin, V.G. et al. The Effects of the Lipid Complex of Extract from the Marine Red Alga Ahnfeltia tobuchiensis (Kanno et Matsubara) Makienko on the Biochemical Parameters of Blood Plasma and Erythrocyte Membranes during Experimental Stress Exposure. Russ J Mar Biol 46, 277–283 (2020). https://doi.org/10.1134/S1063074020040057
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DOI: https://doi.org/10.1134/S1063074020040057