Issue 3, 2021

Life science nanoarchitectonics at interfaces

Abstract

Nanotechnology is an indispensable item in advanced bio-related and life sciences, but a novel concept is necessary to bridge the gaps between nanotechnology and biology/materials chemistry. The most suitable concept for this task would be nanoarchitectonics. In this short review article, our recent accomplishments of nanoarchitectonics approaches in cell functions including gene delivery and controlled differentiation are summarized. Regulation of cell activities by nanoarchitected materials is carried out through their interfacial contacts. Our accomplishments are here described according to the types of material structural motif, (i) nanotopography, (ii) self-assembled structures, and (iii) composite materials. Finally, several challenging approaches are introduced as frontiers of cell fate regulation at interfacial media. Development of artificial materials and systems to regulate bio-organization including living cells will give intuition and ideas even for the design of general functional systems. Interfacial nanoarchitectonics could be an important key concept for future advanced life technologies as well as currently required biomedical applications.

Graphical abstract: Life science nanoarchitectonics at interfaces

Article information

Article type
Review Article
Submitted
22 Aug 2020
Accepted
19 Sep 2020
First published
21 Sep 2020

Mater. Chem. Front., 2021,5, 1018-1032

Life science nanoarchitectonics at interfaces

K. Ariga, K. Tsai, L. K. Shrestha and S. Hsu, Mater. Chem. Front., 2021, 5, 1018 DOI: 10.1039/D0QM00615G

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