Skip to main content

Advertisement

SpringerLink
Log in

Disconnecting surgery at alveus and cornu ammonis of hippocampus, amygdala superficialis, and amygdala medial nuclei for epilepsy associated with attention deficit hyperactivity disorder

  • Case Report
  • Published:
Child's Nervous System Aims and scope Submit manuscript

Abstract

The neural basis for epilepsy and attention deficit hyperactivity disorder (ADHD) is currently incompletely known. We reported a young girl with both epilepsy and ADHD, who had a calcified lesion in the right basolateral amygdalo-hippocampal region extending to the ventral striatum. The child underwent disconnecting surgery and biopsy of the lesion. Fascinatingly, the child’s behavior changed immediately after the surgery from inattentive and impulsive to nearly normal behavior experiencing no more breakthrough seizures since after 3 years of surgery. The Schaltenbrand Wahren Brain Atlas revealed alveus, cornu ammonis, amygdala superficialis, and medium as the disconnected region in this surgery.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Kanner AM, Scharfman H, Jette N, Anagnostou E, Bernard C, Camfield C, Camfield P, Legg K, Dinstein I, Giacobbe P, Friedman A, Pohlmann-Eden B (2017) Epilepsy as a network disorder (1): what can we learn from other network disorders such as autistic spectrum disorder and mood disorders? Epilepsy Behav 77:106–113

    Article  Google Scholar 

  2. Socanski D, Aurlien D, Herigstad A, Thomsen PH, Larsen TK (2013) Epilepsy in a large cohort of children diagnosed with attention deficit/hyperactivity disorders (ADHD). Seizure 22(8):651–655

    Article  Google Scholar 

  3. Vidaurre J, Twanow JDE (2017) Attention deficit hyperactivity disorder and associated cognitive dysfunction in pediatric epilepsy. Semin Pediatr Neurol 24(4):282–291

    Article  Google Scholar 

  4. Plessen KJ, Bansal R, Zhu H, Whiteman R, Amat J, Quackenbush GA, Martin L, Durkin K, Blair C, Royal J, Hugdahl K, Peterson BS (2006) Hippocampus and amygdala morphology in attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 63(7):795–807

    Article  Google Scholar 

  5. Castellanos FX, Giedd JN, Berquin PC, Walter JM, Sharp W, Tran T, Vaituzis AC, Blumenthal JD, Nelson J, Bastain TM, Zijdenbos A, Evans AC, Rapoport JL (2001) Quantitative brain magnetic resonance imaging in girls with attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 58(3):289–295

    Article  CAS  Google Scholar 

  6. Silk TJ, Vilgis V, Adamson C, Chen J, Smit L, Vance A, Bellgrove MA (2016) Abnormal asymmetry in frontostriatal white matter in children with attention deficit hyperactivity disorder. Brain Imaging Behav 10(4):1080–1089

    Article  Google Scholar 

  7. van Ewijk H, Heslenfeld DJ, Zwiers MP, Faraone SV, Luman M, Hartman CA, Hoekstra PJ, Franke B, Buitelaar JK, Oosterlaan J (2014) Different mechanisms of white matter abnormalities in attention-deficit/hyperactivity disorder: a diffusion tensor imaging study. J Am Acad Child Adolesc Psychiatry 53(7):790–799.e793

    Article  Google Scholar 

  8. Posner J, Nagel BJ, Maia TV, Mechling A, Oh M, Wang Z, Peterson BS (2011) Abnormal amygdalar activation and connectivity in adolescents with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 50(8):828–837.e823

    Article  Google Scholar 

  9. Cubillo A, Halari R, Ecker C, Giampietro V, Taylor E, Rubia K (2010) Reduced activation and inter-regional functional connectivity of fronto-striatal networks in adults with childhood attention-deficit hyperactivity disorder (ADHD) and persisting symptoms during tasks of motor inhibition and cognitive switching. J Psychiatr Res 44(10):629–639

    Article  Google Scholar 

  10. Smith AB, Taylor E, Brammer M, Toone B, Rubia K (2006) Task-specific hypoactivation in prefrontal and temporoparietal brain regions during motor inhibition and task switching in medication-naive children and adolescents with attention deficit hyperactivity disorder. Am J Psychiatry 163(6):1044–1051

    Article  Google Scholar 

  11. Aman CJ, Roberts RJ, Pennington BF (1998) A neuropsychological examination of the underlying deficit in attention deficit hyperactivity disorder: frontal lobe versus right parietal lobe theories. Dev Psychol 34(5):956–969

    Article  Google Scholar 

  12. Howes OD, Rogdaki M, Findon JL, Wichers RH, Charman T, King BH, Loth E, McAlonan GM, McCracken JT, Parr JR, Povey C, Santosh P, Wallace S, Simonoff E, Murphy DG (2018) Autism spectrum disorder: consensus guidelines on assessment, treatment and research from the British Association for Psychopharmacology. J Psychopharmacol 32(1):3–29

    Article  Google Scholar 

  13. Oades RD (1998) Frontal, temporal and lateralized brain function in children with attention-deficit hyperactivity disorder: a psychophysiological and neuropsychological viewpoint on development. Behav Brain Res 94(1):83–95

    Article  CAS  Google Scholar 

  14. Yu G, Sharp BM (2015) Basolateral amygdala and ventral hippocampus in stress-induced amplification of nicotine self-administration during reacquisition in rat. Psychopharmacology 232(15):2741–2749

    Article  CAS  Google Scholar 

  15. Schaltenbrand G, Wahren W (1998) Atlas for Stereotaxy of the human brain. Thieme, Stuttgart

    Google Scholar 

  16. Hoogman M, Bralten J, Hibar DP, Mennes M, Zwiers MP, Schweren LSJ, van Hulzen KJE, Medland SE, Shumskaya E, Jahanshad N, Zeeuw P, Szekely E, Sudre G, Wolfers T, Onnink AMH, Dammers JT, Mostert JC, Vives-Gilabert Y, Kohls G, Oberwelland E, Seitz J, Schulte-Rüther M, Ambrosino S, Doyle AE, Høvik MF, Dramsdahl M, Tamm L, van Erp TGM, Dale A, Schork A, Conzelmann A, Zierhut K, Baur R, McCarthy H, Yoncheva YN, Cubillo A, Chantiluke K, Mehta MA, Paloyelis Y, Hohmann S, Baumeister S, Bramati I, Mattos P, Tovar-Moll F, Douglas P, Banaschewski T, Brandeis D, Kuntsi J, Asherson P, Rubia K, Kelly C, Martino AD, Milham MP, Castellanos FX, Frodl T, Zentis M, Lesch KP, Reif A, Pauli P, Jernigan TL, Haavik J, Plessen KJ, Lundervold AJ, Hugdahl K, Seidman LJ, Biederman J, Rommelse N, Heslenfeld DJ, Hartman CA, Hoekstra PJ, Oosterlaan J, Polier GV, Konrad K, Vilarroya O, Ramos-Quiroga JA, Soliva JC, Durston S, Buitelaar JK, Faraone SV, Shaw P, Thompson PM, Franke B (2017) Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults: a cross-sectional mega-analysis. Lancet Psychiatry 4(4):310–319

    Article  Google Scholar 

  17. Park HR, Kim IH, Kang H, Lee DS, Kim BN, Kim DG, Paek SH (2017) Nucleus accumbens deep brain stimulation for a patient with self-injurious behavior and autism spectrum disorder: functional and structural changes of the brain: report of a case and review of literature. Acta Neurochir 159(1):137–143

    Article  Google Scholar 

  18. Sinha S, McGovern RA, Sheth SA (2015) Deep brain stimulation for severe autism: from pathophysiology to procedure. Neurosurg Focus 38(6):E3

    Article  Google Scholar 

  19. Sturm V, Fricke O, Buhrle CP, Lenartz D, Maarouf M, Treuer H, Mai JK, Lehmkuhl G (2012) DBS in the basolateral amygdala improves symptoms of autism and related self-injurious behavior: a case report and hypothesis on the pathogenesis of the disorder. Front Hum Neurosci 6:341

    PubMed  Google Scholar 

  20. Sripada C, Kessler D, Fang Y, Welsh RC, Prem Kumar K, Angstadt M (2014) Disrupted network architecture of the resting brain in attention-deficit/hyperactivity disorder. Hum Brain Mapp 35(9):4693–4705

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kota Bharu, Kelantan, Malaysia

    Zamzuri Idris, Zaitun Zakaria, Abdul Rahman Izaini Ghani & Jafri Malin Abdullah

  2. Brain And Behaviour Cluster, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kota Bharu, Kelantan, Malaysia

    Zamzuri Idris, Zaitun Zakaria, Abdul Rahman Izaini Ghani & Jafri Malin Abdullah

  3. Hospital Universiti Sains Malaysia, Universiti Sains Malaysia, Health Campus, Jalan Raja Perempuan Zainab 2, 16150, Kota Bharu, Kelantan, Malaysia

    Zamzuri Idris, Zaitun Zakaria, Sanihah Abdul Halim, Salmi Abd Razak, Abdul Rahman Izaini Ghani & Jafri Malin Abdullah

  4. Neurology Unit, Department of Internal Medicine, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kota Bharu, Kelantan, Malaysia

    Sanihah Abdul Halim

  5. Department of Pediatrics, School of Medical Sciences, Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia

    Salmi Abd Razak

Authors
  1. Zamzuri Idris
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Zaitun Zakaria
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sanihah Abdul Halim
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Salmi Abd Razak
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Abdul Rahman Izaini Ghani
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Jafri Malin Abdullah
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Zamzuri Idris.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Electronic supplementary material

ESM 1

The video shows patient’s condition at preoperative period, at seven day and one year after the surgery. Noteworthy that marked improvement was immediately noted after the resective-disconnecting surgery. (WMV 191049 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Idris, Z., Zakaria, Z., Halim, S.A. et al. Disconnecting surgery at alveus and cornu ammonis of hippocampus, amygdala superficialis, and amygdala medial nuclei for epilepsy associated with attention deficit hyperactivity disorder. Childs Nerv Syst 37, 1797–1802 (2021). https://doi.org/10.1007/s00381-020-04893-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00381-020-04893-z

Keywords

Search

Navigation