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Indole Alkaloids from Hosta plantaginea and Inhibition of Steroid 5α-Reductase Activities In Vitro

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Chemistry of Natural Compounds Aims and scope

A new indole alkaloid (1), together with eight known indole alkaloid derivatives (2–9), was isolated from Hosta plantaginea for the first time. The structures of compounds 1–9 were elucidated on the basis of comprehensive spectroscopic analyses and references. Compounds 1–9 were evaluated for their inhibition of steroid 5α-reductase activity in vitro. Among them, compounds 1 and 2 showed important inhibition of steroid 5α-reductase activities.

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Acknowledgment

This research program is financially supported by the National Natural Science Foundation of China (81803843), the Scientific Research Project of Jiangxi Administration of Traditional Chinese Medicine (2019A002, 2019A018), the Standard Revision Research Project of National Pharmacopoeia Committee (2018Z090), the Science and Technology Project of Jiangxi Provincial Department of Education (GJJ180688, GJJ180662), the Science and Technology Project of Jiangxi Health Commission (20195650, 20195648), the Scientific Research Project of First-class Discipline of Chinese Materia Medica of Jiangxi University of TCM (JXSYLXK-ZHYAO027, JXSYLXK-ZHYAO032), and the Doctoral Research Initiation Fund Project of Jiangxi University of TCM (2018BSZR010, 2018BSZR007).

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Authors and Affiliations

  1. Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Key Laboratory of Modern Preparation of TCM of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, 330004, Nanchang, Jiangxi, P. R. China

    Rongrui Wei & Qinge Ma

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  1. Rongrui Wei
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  2. Qinge Ma
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Correspondence to Qinge Ma.

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Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2020, pp. 760–762.

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Wei, R., Ma, Q. Indole Alkaloids from Hosta plantaginea and Inhibition of Steroid 5α-Reductase Activities In Vitro. Chem Nat Compd 56, 888–891 (2020). https://doi.org/10.1007/s10600-020-03176-y

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  • DOI: https://doi.org/10.1007/s10600-020-03176-y

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