Issue 37, 2020

Aromatic carbohydrate amphiphile disrupts cancer spheroids and prevents relapse

Abstract

Spheroids recapitulate the organization, heterogeneity and microenvironment of solid tumors. Herein, we targeted spatiotemporally the accelerated metabolism of proliferative cells located on the spheroid surface that ensure structure maintenance and/or growth. We demonstrate that phosphorylated carbohydrate amphiphile acts as a potent antimetabolite due to glycolysis inhibition and to in situ formation of supramolecular net around spheroid surface where alkaline phosphatase is overexpressed. The efficiency of the treatment is higher in spheroids as compared to the conventional 2D cultures because of the 2-fold higher expression of glucose transporter 1 (GLUT1). Moreover, treated spheroids do not undergo following relapse.

Graphical abstract: Aromatic carbohydrate amphiphile disrupts cancer spheroids and prevents relapse

Supplementary files

Article information

Article type
Communication
Submitted
03 Jul 2020
Accepted
14 Sep 2020
First published
15 Sep 2020

Nanoscale, 2020,12, 19088-19092

Author version available

Aromatic carbohydrate amphiphile disrupts cancer spheroids and prevents relapse

A. Brito, P. M. R. Pereira, R. L. Reis, R. V. Ulijn, J. S. Lewis, R. A. Pires and I. Pashkuleva, Nanoscale, 2020, 12, 19088 DOI: 10.1039/D0NR05008C

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