Abstract
A spectrometer based on silicon nanosandwiches (SNSs) is proposed for problems of personalized medicine. SNS structures exhibit properties of terahertz (THz) emitter and receiver of the THz response of biological tissue. Measurements of the I–V characteristics of the SNS structure make it possible to analyze the spectral composition of the THz response of biological tissue and determine relative contributions of various proteins and amino acids contained in the structure of DNA oligonucleotides and the corresponding compounds. Evident advantages of the proposed method are related to the fact that the THz response can be directly obtained from living biological tissue and, hence, used for express analysis of the DNA oligonucleotides. Tests of several control groups show that the further analysis of the specific features of the spectral peaks of the SNS I–V characteristics is of interest for methods of personalized diagnostics and treatment.
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Funding
This work was supported by the Research Program of the Ioffe Physicotechnical Institute, Russian Academy of Sciences.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants involved in the study.
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Translated by A. Chikishev
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Bagraev, N.T., Klyachkin, L.E., Malyarenko, A.M. et al. Terahertz Response of Biological Tissue for Diagnostic and Treatment in Personalized Medicine. Tech. Phys. 65, 1442–1445 (2020). https://doi.org/10.1134/S1063784220090066
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DOI: https://doi.org/10.1134/S1063784220090066