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Fabrication of Cylindrical Magnetic Nanoparticles for Functionalization of Polyelectrolyte Microcapsules

  • NANOMATERIALS IN BIOLOGY AND MEDICINE
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Abstract

A problem of fabrication of magnetic polymer capsules for targeted drug delivery is considered. Magnetic nanoparticles are used in the problem under study. A method for fabrication of such particles involving synthesis of layered nanowires with alternating layers of the specified magnetic metal and sacrificial layers of nonmagnetic metal is proposed. A method for template-assisted synthesis based on ac-potential electroplating of specified metals in the pores of track membranes is used to fabricate wires with a diameter of 100 nm with nickel layers of 400 and 200 nm. A method for the subsequent extraction of nickel fragments using selective etching (removal) of copper fragments is developed. Procedures that prevent aggregation of magnetic nanoparticles and penetration of the nanoparticles in the shells of polymer capsules are considered.

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ACKNOWLEDGMENTS

We are grateful to P.Yu. Apel’ for providing track membranes and R. Kamyshinskii for the SEM study of the capsules.

Funding

This work was supported by the Ministry of Science and Higher Education of the Russian Federation in the framework of the State Contract using Core Facility of the Crystallography and Photonics Research Center. The synthesis and characterization of magnetic nanowires were supported by the Ministry of Education and Science of the Russian Federation (project RFMEFI62119X0035). Fabrication of the magnetized capsules was supported in part by the Russian Foundation for Basic Research (project no. 18-53-34007 “Kuba_t”).

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Authors and Affiliations

  1. Federal Research Center Crystallography and Photonics, Russian Academy of Sciences, 119333, Moscow, Russia

    I. M. Doludenko, A. V. Mikheev, I. A. Burmistrov, D. B. Trushina, T. N. Borodina, T. V. Bukreeva & D. L. Zagorskii

  2. Moscow State University, 119991, Moscow, Russia

    A. V. Mikheev

  3. Sechenov First Moscow State Medical University, 119991, Moscow, Russia

    D. B. Trushina & T. N. Borodina

  4. National Research Center Kurchatov Institute, 123098, Moscow, Russia

    T. V. Bukreeva

Authors
  1. I. M. Doludenko
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  2. A. V. Mikheev
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  3. I. A. Burmistrov
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  4. D. B. Trushina
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  5. T. N. Borodina
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  6. T. V. Bukreeva
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  7. D. L. Zagorskii
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Correspondence to I. M. Doludenko.

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The authors declare that they have no conflicts of interest.

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Translated by A. Chikishev

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Doludenko, I.M., Mikheev, A.V., Burmistrov, I.A. et al. Fabrication of Cylindrical Magnetic Nanoparticles for Functionalization of Polyelectrolyte Microcapsules. Tech. Phys. 65, 1377–1383 (2020). https://doi.org/10.1134/S1063784220090121

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  • DOI: https://doi.org/10.1134/S1063784220090121

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