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Isolation and Cytotoxicity of Isocoumarins from the Entomogenous Fungus Setosphaeria sp.

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Chemistry of Natural Compounds Aims and scope

A new isocoumarin compound named setosphacohol A (1), together with six known ones, alternariol (2), isoaltenuene (3), phomasatin (4), alternariol 5-O-methyl ether (5), 1-deoxyrubralactone (6), and rubralactone (7), was isolated from the entomogenous fungus Setosphaeria sp. The structure of the new compound was elucidated by analysis of the 1D and 2D spectroscopic data as well as MS. Compounds 2, 5, 6 showed moderate cytotoxicity against six human tumor cell lines MCF-7, MGC-803, H1975, Huh-7, A549, and HeLa with IC50 values ranging from 23.04 to 96.91 μg·mL–1.

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Acknowledgment

This work was kindly supported by the Post-graduate′s Innovation Fund Project of Hebei Province (Project CXZZBS2019026), the National Key Research and Development Program of China (2017YFD0201401), and the Central Public-Interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences (17CXTD-15; 1630052016008).

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Authors and Affiliations

  1. College of Life Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, 071002, Baoding, P. R. China

    Sha-Sha Liu, Wen-Bin Gao, Jie Kang, Xiao-Hui Yang, Fei Cao & Du-Qiang Luo

  2. Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, 571101, Haikou, P. R. China

    Fan-Dong Kong & You-Xing Zhao

Authors
  1. Sha-Sha Liu
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  2. Wen-Bin Gao
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  3. Jie Kang
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  4. Xiao-Hui Yang
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  5. Fei Cao
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  6. Fan-Dong Kong
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  7. You-Xing Zhao
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  8. Du-Qiang Luo
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Corresponding authors

Correspondence to You-Xing Zhao or Du-Qiang Luo.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2020, pp. 688–690.

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Liu, SS., Gao, WB., Kang, J. et al. Isolation and Cytotoxicity of Isocoumarins from the Entomogenous Fungus Setosphaeria sp.. Chem Nat Compd 56, 799–802 (2020). https://doi.org/10.1007/s10600-020-03155-3

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  • DOI: https://doi.org/10.1007/s10600-020-03155-3

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