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Ion exchange resin-catalyzed synthesis of bridged tetraoxanes possessing in vitro cytotoxicity against HeLa cancer cells

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Chemistry of Heterocyclic Compounds Aims and scope

Bridged 1,2,4,5-tetraoxanes were prepared using available acidic ion exchange resin with high yields despite the possibility of peroxide decomposition under heterogeneous conditions. The bridged tetraoxanes demonstrated high cytotoxicity against HeLa cancer cells in vitro, which in some cases was higher than that of cisplatin, artesunate, and dihydroartemisinin.

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This work was supported by the Russian Foundation for Basic Research according to the research project No. 18-53-15010 and Projects de Recherche Conjoints (PRC) – CNRS, PRC Russie 2017 CNRS.

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave, Moscow, 119991, Russia

    Vera A. Vil’, Ivan A. Yaremenko, Dmitri I. Fomenkov & Alexander O. Terent’ev

  2. Mechanism and Regulation of DNA Repair Team, Université de Nantes, UFIP CNRS UMR 6286, 2 rue de la Houssinière, 44322, Nantes, France

    Dmitri O. Levitsky & Fabrice Fleury

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  1. Vera A. Vil’
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  2. Ivan A. Yaremenko
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  3. Dmitri I. Fomenkov
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  4. Dmitri O. Levitsky
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  6. Alexander O. Terent’ev
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Correspondence to Alexander O. Terent’ev.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2020, 56(6), 722–726

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Vil’, V.A., Yaremenko, I.A., Fomenkov, D.I. et al. Ion exchange resin-catalyzed synthesis of bridged tetraoxanes possessing in vitro cytotoxicity against HeLa cancer cells. Chem Heterocycl Comp 56, 722–726 (2020). https://doi.org/10.1007/s10593-020-02722-4

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