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Synthesis and study of cytotoxic activity of novel 3,3-bis(indol-3-yl)-1,3-dihydroindol-2-ones

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Chemistry of Heterocyclic Compounds Aims and scope

A series of 3,3-bis(indol-3-yl)-1,3-dihydroindol-2-ones containing substituents at different positions of the oxindole ring were synthesized to study the effect of the position of the substituent on biological activity. Some of the new derivatives showed high in vitro cytotoxic activity (MTT assay) on human tumor cell lines and lower (60 and 150 times less) cytotoxicity on donor human fibroblasts compared to doxorubicin.

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The study was supported by the Russian Science Foundation (project No. 16-15-10300).

Victor V. Tatarskiy expresses his personal gratitude for the financial support to the Ministry of Science and Higher Education of the Russian Federation in the framework of the competitiveness program of National University of Science and Technology MISiS (grant Z02-2017-2-1).

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Authors and Affiliations

  1. Gause Institute of New Antibiotics, 11 B. Pirogovskaya St, Moscow, 119021, Russia

    Sergey N. Lavrenov, Olga P. Bychkova, Lyubov G. Dezhenkova, Elena A. Tsvigun & Alexey S. Trenin

  2. Volgograd State Technical University, 28 Lenina Ave, Volgograd, 400005, Russia

    Arthur S. Mkrtchyan

  3. N. N. Blokhin Russian Cancer Research Center, 24 Kashirskoe shosse, Moscow, 115478, Russia

    Victor V. Tatarskiy

  4. National University of Science and Technology MISiS, 4 Leninsky Ave, Moscow, 119049, Russia

    Victor V. Tatarskiy

Authors
  1. Sergey N. Lavrenov
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  2. Olga P. Bychkova
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  3. Lyubov G. Dezhenkova
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  4. Arthur S. Mkrtchyan
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  5. Victor V. Tatarskiy
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  6. Elena A. Tsvigun
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  7. Alexey S. Trenin
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Corresponding author

Correspondence to Sergey N. Lavrenov.

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In memory of Professor Maria Nikolaevna Preobrazhenskaya

Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2020, 56(6), 741–746

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Lavrenov, S.N., Bychkova, O.P., Dezhenkova, L.G. et al. Synthesis and study of cytotoxic activity of novel 3,3-bis(indol-3-yl)-1,3-dihydroindol-2-ones. Chem Heterocycl Comp 56, 741–746 (2020). https://doi.org/10.1007/s10593-020-02725-1

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  • DOI: https://doi.org/10.1007/s10593-020-02725-1

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