Elsevier

Microbes and Infection

Volume 22, Issue 10, November–December 2020, Pages 525-533
Microbes and Infection

Transcriptional ups and downs: patterns of gene expression in the life cycle of Toxoplasma gondii

https://doi.org/10.1016/j.micinf.2020.09.001Get rights and content
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Abstract

Toxoplasma gondii reproduces sexually in felines and asexually in virtually all warm-blooded animals, including humans. This obligate intracellular parasite alternates between biologically distinct developmental stages throughout its complex life cycle. Stage conversion is crucial for T. gondii transmission, persistence, and the maintenance of genetic diversity within the species. Genome-wide comparative transcriptomic studies have contributed invaluable insights into the regulatory gene networks underlying T. gondii development.

Keywords

Toxoplasma gondii
Regulation of gene expression
Transcriptomics
Development differentiation

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Contributed equally to this work.