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A Convenient One-Pot Synthesis of 1,5-Disubstituted Tetrazoles Containing an Amino or a Carboxy Group

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Abstract

A convenient method is proposed for constructing the tetrazole ring by a one-pot reaction of amides with phosphorus oxychloride and sodium azide. A series of 1,5-disubstituted tetrazoles containing an amino or a carboxy group, which present interest as buildings blocks for the synthesis of biologically active substances, were obtained.

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Authors and Affiliations

  1. Ivan Franko National University of Lviv, 79005, Lviv, Ukraine

    N. T. Pokhodylo, O. Ya. Shyyka & M. D. Obushak

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  1. N. T. Pokhodylo
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  2. O. Ya. Shyyka
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  3. M. D. Obushak
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Correspondence to M. D. Obushak.

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Pokhodylo, N.T., Shyyka, O.Y. & Obushak, M.D. A Convenient One-Pot Synthesis of 1,5-Disubstituted Tetrazoles Containing an Amino or a Carboxy Group. Russ J Org Chem 56, 802–812 (2020). https://doi.org/10.1134/S1070428020050127

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