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A Modified Synthesis of Oxetan-3-ol

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Abstract

A highly regioselective ring opening reaction of terminal epoxides with 2-bromobenzoic acid catalyzed by tetrabutylammonium bromide was accomplished. The procedure is operationally simple and practical for the synthesis of a series of β-hydroxy esters. Using this protocol, oxetan-3-ol could be prepared efficiently in a good yield.

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ACKNOWLEDGMENTS

We are grateful to the Laboratory of Organic Functional Molecules, Sino–French Institute of ECNU for financial support.

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Authors and Affiliations

  1. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, 200241, Shanghai, China

    X. Y. Xia, W. Sun, W. He, Y. Feng, L. Zhan & Y. Luo

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  1. X. Y. Xia
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  2. W. Sun
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  3. W. He
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  4. Y. Feng
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Correspondence to Y. Luo.

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Xia, X.Y., Sun, W., He, W. et al. A Modified Synthesis of Oxetan-3-ol. Russ J Org Chem 56, 877–883 (2020). https://doi.org/10.1134/S107042802005022X

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  • DOI: https://doi.org/10.1134/S107042802005022X

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