Skip to main content
SpringerLink
Log in

New Polysubstituted Pyrazole Derivatives: Synthesis and Cytotoxicity Studies

  • Published:
Russian Journal of General Chemistry Aims and scope Submit manuscript

Abstract

Several new 1,3,4-trisubstituted pyrazoles are synthesized from (E)-3-[1-(3-chlorophenyl)-3-(4-methoxyphenyl)-1H-pyrazol-4-yl]-1-(pyridin-3-yl)prop-2-en-1-one and their structures are supported by specral methods. The in vitro cytotoxicity tests of selected compounds against MCF-7 cell line demonstrate the strong effect of some of those in comparison with doxorubicin.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme
Scheme
Scheme
Fig. 1.

Similar content being viewed by others

REFERENCES

  1. Elzahabi, H.S., Nossier, E.S., Khalifa, N.M., Alasfoury, R.A., and El-Manawaty, M.A., J. Enzym. Inhib. Med. Chem., 2018, vol. 33, p. 546. https://doi.org/10.1080/14756366.2018.1437729

    Article  CAS  Google Scholar 

  2. Fahmy, H.H., Khalifa, N.M., Ismail, M.F., El-Sahrawy, H.M., and Nossier, E.S., Molecules, 2016, vol. 21, p. 271. https://doi.org/10.3390/molecules21030271

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Hawash, M.M., Kahraman, D.C., Eren, F., Atalay, R.C., and Baytas, S.N., Eur. J. Med. Chem., 2017, vol. 129, p. 12. https://doi.org/10.1016/j.ejmech.2017.02.002

    Article  CAS  PubMed  Google Scholar 

  4. Ismail, M.F., Khalifa, N.M., Fahmy, H.H., Nossier, E.S., and Abdulla, M.M., J. Heterocycl. Chem., 2014, vol. 51, p. 450. https://doi.org/10.1002/jhet.1757

    Article  CAS  Google Scholar 

  5. Harras, M.F. and Sabour, R., Bioorg. Chem., 2018, vol. 78, p. 149. https://doi.org/10.1016/j.bioorg.2018.03.014

    Article  CAS  PubMed  Google Scholar 

  6. Abdellatif, K.R., Fadaly, W.A., Elshaier, Y.A., Ali, W.A., and Kamel, G.M., Bioorg. Chem., 2018, vol. 77, p. 568. https://doi.org/10.1016/j.bioorg.2018.02.018

    Article  CAS  PubMed  Google Scholar 

  7. Abd El-Meguid, E.A. and Ali, M.M., Res. Chem. Intermed., 2016, vol. 42, p.1521. https://doi.org/10.1007/s11164-015-2100-8

    Article  CAS  Google Scholar 

  8. Khalifa, N.M., Ramla, M.M., Amr, A.E., and Abdulla, M.M., Phosph., Sulfur, Silicon, Relat. Elements, 2008, vol. 183, no. 12, p. 3046. https://doi.org/10.1080/10426500802059885

    Article  CAS  Google Scholar 

  9. Soerensen, M.D., Khalifa, N.M., and Pedersen, E.B., Synthesis, 1999, vol. 11, p. 1937.

    Article  Google Scholar 

  10. El Nezhawy, A.O., Ramla, M.M., Khalifa, N.M., and Abdulla, M.M., Monatsh Chem., 2009, vol. 140, p. 531. https://doi.org/10.1007/s00706-008-0085-3

    Article  CAS  Google Scholar 

  11. Vichai, V. and Kirtikara, K., Nat. Protoc., 2006, vol. 1, no. 3, p. 1112. https://doi.org/10.1038/nprot.2006.179

    Article  CAS  PubMed  Google Scholar 

  12. Molecular Operating Environment (MOE), 2015.08; Chemical Computing Group Inc.: Montreal, QC, Canada, 2015.

Download references

Funding

Authors are grateful to King Saud University for funding the work through Researchers Supporting Project (project no. RSP-2020/66).

Author information

Authors and Affiliations

  1. Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, 11451, Riyadh, Saudi Arabia

    N. M. Khalifa, M. A. Al-Omar & A. E. Amr

  2. Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Division, National Research Centre, Dokki, 12622, Cairo, Egypt

    N. M. Khalifa & H. H. Fahmy

  3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, 11754, Cairo, Egypt

    E. S. Nossier

  4. Applied Organic Chemistry Department, National Research Centre, Cairo, 12622, Dokki, Egypt

    A. E. Amr

Authors
  1. N. M. Khalifa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. H. Fahmy
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. S. Nossier
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. A. Al-Omar
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. E. Amr
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to N. M. Khalifa.

Ethics declarations

No conflict of interest was declared by the authors.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Khalifa, N.M., Fahmy, H.H., Nossier, E.S. et al. New Polysubstituted Pyrazole Derivatives: Synthesis and Cytotoxicity Studies. Russ J Gen Chem 90, 1062–1068 (2020). https://doi.org/10.1134/S1070363220060201

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1070363220060201

Keywords:

Search

Navigation