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Laser Correlation Spectrometer for Assessing the Size and Dynamics of Changes in the Size of Structures in Biological Fluids

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Abstract

To estimate the size of nanostructures in biological fluids and study the dynamics of their change, a modified method of laser correlation spectroscopy is proposed. The scheme of the hardware-software complex and the algorithm of the method are described, which allows one to achieve high accuracy in determining the size of nanoparticles, as well as to study the process of changing the size of nanoparticles in dynamics. The proposed hardware-software complex made it possible to study the dynamics of the formation of aggregates in human serum in the process of immune response. The results obtained indicate the presence of processes of rapid protein aggregation as a result of activation of the immune response. In addition, the size of the aggregates formed depends on the state of the immune system and the presence of diseases.

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ACKNOWLEDGMENTS

The authors thank Bogomaz T.A. for comprehensive assistance and valuable scientific advice.

Funding

This research work was supported by the Peter the Great St. Petersburg Polytechnic University in the framework of the Program “5-100-2020.”

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Authors and Affiliations

  1. Peter the Great St. Petersburg Polytechnic University, 195251, St. Petersburg, Russia

    E. N. Velichko, E. K. Nepomnyashchaya & T. Yu. Kudryashova

  2. State Research Center of the Russian Federation Concern CSRI Elektropribor, JSC, 197046, St. Petersburg, Russia

    A. V. Sokolov

Authors
  1. E. N. Velichko
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  2. E. K. Nepomnyashchaya
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  3. A. V. Sokolov
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  4. T. Yu. Kudryashova
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Corresponding author

Correspondence to E. K. Nepomnyashchaya.

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ETHICAL COMPLIANCE

All procedures performed in a human study correspond to ethical standards of the institutional and/or national committee on research ethics and the 1964 Helsinki Declaration and its subsequent changes or comparable ethical standards.

CONFLICT OF INTEREST

The authors declare that they have no conflicts of interest.

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Translated by N. Petrov

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Velichko, E.N., Nepomnyashchaya, E.K., Sokolov, A.V. et al. Laser Correlation Spectrometer for Assessing the Size and Dynamics of Changes in the Size of Structures in Biological Fluids. Opt. Spectrosc. 128, 959–963 (2020). https://doi.org/10.1134/S0030400X20070255

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  • DOI: https://doi.org/10.1134/S0030400X20070255

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