Abstract
We consider some piecewise linear 4-dimensional dynamical system that models a gene network regulated by one negative feedback and three positive feedbacks. Glass and Pasternack described the conditions for the existence of a stable cycle in this model. We construct an invariant piecewise linear surface with nontrivial link with the Glass-Pasternack cycle outside the attraction domain of this stable cycle in the phase portrait of this system.
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A. A. Akinshin, V. P. Golubyatnikov, and I. V. Golubyatnikov, “On Some Multidimensional Models of Gene Network Functioning,” Sibir. Zh. Industr. Mat. 16 (1), 3–9 (2013) [J. Appl. Indust. Math. 7 (3), 296–301 (2013)].
N. B. Ayupova and V. P. Golubyatnikov, “On the Uniqueness of a Cycle in an Asymmetric Three-Dimensional Model of a Molecular Repressilator,” Sibir. Zh. Industr. Mat. 17 (1), 3–7 (2014) [J. Appl. Indust. Math. 8(2), 153–157 (2014)].
N. B. Ayupova and V. P. Golubyatnikov, “On Two Classes of Nonlinear Dynamical Systems: The Four-Dimensional Case,” Sibir. Mat. Zh. 56 (2), 282–289 (2015) [Siberian Math. J. 56 (2), 231–236 (2015)].
M. V. Kazantsev, “About Some Properties of Graphs of Domains of Dynamical Systems,” Sibir. Zh. Industr. Mat. 18 (4), 42–49 (2015).
H. T. Banks and J. M. Mahaffy, “Stability of Cyclic Gene Models for Systems Involving Repression,” J. Theor. Biol. 74, 323–334 (1978).
L. Glass and J. S. Pasternack, “Stable Oscillations in Mathematical Models of Biological Control Systems,” J. Math. Biol. 6, 207–223 (1978).
V. A. Likhoshvai, S. I. Fadeev, V. V. Kogai, and T. M. Khlebodarova, “Alternative Splicing Can Lead to Chaos,” J. Bioinform. Comput. Biol. 13 (1), 1540003–1–1540003–25 (2015).
S. P. Hastings, J. Tyson, and D. Webster, “Existence of Periodic Solutions for Negative Feedback Cellular Control Systems,” J. Differential Equations 25, 39–64 (1977).
V. P. Golubyatnikov and A. E. Kalenykh, “Structure of Phase Portraits of Nonlinear Dynamical Systems,” Vestnik Novosib. Gos. Univ. Ser. Mat. Mekh. Inform. 15 (1), 45–53 (2015) [J. Math. Sci. 215 (4), 475–483 (2016)].
V. P. Golubyatnikov and V. V. vanov, “Uniqueness and Stability of a Cycle in a Three-Dimensional Block Linear Model of Cyclic Gene Networks,” Sibir. Zh. Chist. i Prikl. Mat. 18 (4), 19–28 (2018).
S. Tabachnikov, Geometry and Billiards (AM, Providence, RI, 2005; Izd. Izhevsk. Inst. Komput. Issled, Moscow, 2011).
V. P. Golubyatnikov and M. V. Kazantsev, “Piecewise Linear Dynamical System Modeling Gene Network with Variable Feedback,” Sibir. Zh. Chist. i Prikl. Mat. 16 (4), 28–37 (2016) [J. Math. Sci. 230 (1), 46–54 (2018)].
R. A. Horn and Ch. R. Johnson, Matrix Analysis (Cambridge Univ. Pres, New York, 1986; Mir, Moscow, 1989).
V. G. Turaev, Quantum Invariants of Knots and 3-Manifolds (Walter de Gruyter, Berlin, 2010).
Acknowledgment
The authors express their sincere gratitude to V. G. Bardakov, M. V. Neschadim, and V. A. Churkin for useful discussions and critical remarks.
Funding
The authors were supported by the Russian Foundation for Basic Research (project no. 18-01-00057) and Program No. I.5.1 of Basic Scientific Research of the Siberian Branch of the Russian Academy of Sciences (project no. 0314-2018-0011).
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Russian Text © The Author(s), 2019, published in Sibirskii Zhurnal Industrial’noi Matematiki, 2019, Vol. XXII, No. 4, pp. 19-25.
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Ayupova, N.B., Golubyatnikov, V.P. Structure of the Phase Portrait of a Piecewise-Linear Dynamical System. J. Appl. Ind. Math. 13, 606–611 (2019). https://doi.org/10.1134/S1990478919040033
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DOI: https://doi.org/10.1134/S1990478919040033