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Three-Component Reaction of Pyrrolediones, Malononitrile, and Acyclic Enols

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Abstract

Three-component condensation of ethyl 1-R-2-phenyl-4,5-dihydro-4,5-dioxo-1H-pyrrole-3-carboxylates, malononitrile, and acyclic enols (acetylacetone, alkyl acetoacetates, and ethyl benzoylacetate) afforded substituted ethyl 9-amino-10-cyano-1-oxo-3-phenyl-8-oxa-2-azaspiro[4.5]deca-3,6,9-triene-4-carboxylates. The products are interesting from the viewpoint of medicinal chemistry.

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Funding

This study was performed under financial support by the Ministry of Science and Higher Education of the Russian Federation (project no. FCHF-2020-0008) and by the Government of Perm Krai.

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Authors and Affiliations

  1. Perm State University, 614990, Perm, Russia

    A. A. Sabitov, M. V. Dmitriev, A. I. Belozerova, T. V. Sal’nikova & A. N. Maslivets

Authors
  1. A. A. Sabitov
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  2. M. V. Dmitriev
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  3. A. I. Belozerova
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  4. T. V. Sal’nikova
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  5. A. N. Maslivets
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Correspondence to A. N. Maslivets.

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Sabitov, A.A., Dmitriev, M.V., Belozerova, A.I. et al. Three-Component Reaction of Pyrrolediones, Malononitrile, and Acyclic Enols. Russ J Org Chem 56, 1217–1221 (2020). https://doi.org/10.1134/S1070428020070155

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  • DOI: https://doi.org/10.1134/S1070428020070155

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