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A new disposable electrochemical sensor on medical adhesive tape

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Abstract

In this work, the use of medical adhesive tape—as a substrate to develop novel sensor architecture for the detection of hemoglobin (HB) has been investigated. The electrodes were fabricated based on the screen-printing method. The proposed electrode was characterized by scanning electron microscopy, energy-dispersive X-ray spectroscopy, and cyclic voltammetry. The medical adhesive electrode showed excellent electrochemical behavior for dopamine, which was used for characterization and proof of concept. Also, the electrode was applied for HB electrochemical detection in the range of 1.0 to 10 mg mL−1, with a detection limit of 0.7 mg mL−1 by using differential pulse voltammetry. This sensor has shown resistance to mechanical stress, even when deformed based on its wearable functions, which is an exciting alternative for the development of low-cost electrochemical devices.

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References

  1. Tricoli A, Nasiri N, De S (2017) Wearable and miniaturized sensor technologies for personalized and preventive medicine. Adv Funct Mater 27(15):1605271

    Article  Google Scholar 

  2. Ramos MMV, Carvalho JHS, de Oliveira PR, Janegitz BC (2020) Determination of serotonin by using a thin film containing graphite, nanodiamonds and gold nanoparticles anchored in casein. Measurement 149:106979

    Article  Google Scholar 

  3. Zambianco NA, Silva TA, Zanin H, Fatibello-Filho O, Janegitz BC (2019) Novel electrochemical sensor based on nanodiamonds and manioc starch for detection of diquat in environmental samples. Diam Relat Mater 98:107512

    Article  CAS  Google Scholar 

  4. Kim J, Campbell AS, de Ávila BE-F, Wang J (2019) Wearable biosensors for healthcare monitoring. Nat Biotechnol 37(4):389–406

    Article  CAS  Google Scholar 

  5. Czech Z, Kowalczyk A (2011) Pressure-sensitive adhesives for medical applications. In: IntechOpen (Ed.), Wide spectra of quality control. IntechOpen, Rijeka, Croatia, pp. 309–332

  6. Parlak O, Keene ST, Marais A, Curto VF, Salleo A (2018) Molecularly selective nanoporous membrane-based wearable organic electrochemical device for noninvasive cortisol sensing. Sci Adv 4(7):eaar2904

    Article  CAS  Google Scholar 

  7. Guinovart T, Valdés-Ramírez G, Windmiller JR, Andrade FJ, Wang J (2014) Bandage-based wearable potentiometric sensor for monitoring wound pH. Electroanalysis 26(6):1345–1353

    Article  CAS  Google Scholar 

  8. Hussain KK, Moon J-M, Park D-S, Shim Y-B (2017) Electrochemical detection of hemoglobin: a review. Electroanalysis 29(10):2190–2199

    Article  CAS  Google Scholar 

  9. Toh RJ, Peng WK, Han J, Pumera M (2014) Direct in vivo electrochemical detection of haemoglobin in red blood cells. Sci Rep 4:6209

    Article  CAS  Google Scholar 

  10. Marengo-Rowe AJ (2006) Structure-function relations of human hemoglobins. Proc (Baylor Univ Med Cent) 19(3):239–245

    Article  Google Scholar 

  11. Giardina B, Messana I, Scatena R, Castagnola M (1995) The multiple functions of hemoglobin. Crit Rev Biochem Mol Biol 30(3):165–196

    Article  CAS  Google Scholar 

  12. Gell DA (2018) Structure and function of haemoglobins. Blood Cells Mol Dis 70:13–42

    Article  CAS  Google Scholar 

  13. Thomas C, Lumb AB (2012) Physiology of haemoglobin. CEACCP 12(5):251–256

    Google Scholar 

  14. Laube N, Mohr B, Hesse A (2001) Laser-probe-based investigation of the evolution of particle size distributions of calcium oxalate particles formed in artificial urines. J Cryst Growth 233(1):367–374

    Article  CAS  Google Scholar 

  15. The Soap and Detergent Association (1990) Glycerine: an overview. Terms, technical data, properties, performance

  16. Pagliaro M, Rossi M (2010) Glycerol: properties and production. In: The Future of Glycerol, pp 20–21

    Google Scholar 

  17. Pradela-Filho LA, Araújo DAG, Takeuchi RM, Santos AL (2017) Nail polish and carbon powder: an attractive mixture to prepare paper-based electrodes. Electrochim Acta 258:786–792

    Article  CAS  Google Scholar 

  18. Dias IARB, Saciloto TR, Cervini P, Cavalheiro ETG (2017) Determination of epinephrine at a screen-printed composite electrode based on graphite and polyurethane. J Anal Bioanal Tech 8(350):1–6

    Google Scholar 

  19. López-López M, Vaz J, García-Ruiz C (2015) Confocal Raman spectrocopy for the analysis of nail polish evidence. Talanta 138:155–162

    Article  Google Scholar 

  20. Bard AJ, Faulkner LR, Leddy J, Zoski CG (1980) Electrochemical methods: fundamentals and applications. Wiley, New York

    Google Scholar 

  21. Amatore C, Savéant J (1978) Do ECE mechanisms occur in conditions where they could be characterized by electrochemical kinetic techniques? J Electroanal Chem Interfacial Electrochem 86(1):227–232

    Article  CAS  Google Scholar 

  22. Amatore C, Nadjo L, Savéant J (1978) Convolution and finite difference approach: application to cyclic voltammetry and spectroelectrochemistry. J Electroanal Chem Interfacial Electrochem 90(3):321–331

    Article  CAS  Google Scholar 

  23. Ciolkowski EL, Maness KM, Cahill PS, Wightman RM, Evans DH, Fosset B, Amatore C (1994) Disproportionation during electrooxidation of catecholamines at carbon-fiber microelectrodes. Anal Chem 66(21):3611–3617

    Article  CAS  Google Scholar 

  24. Ciolkowski EL, Cooper BR, Jankowski JA, Jorgenson JW, Wightman RM (1992) Direct observation of epinephrine and norepinephrine cosecretion from individual adrenal medullary chromaffin cells. J Am Chem Soc 114(8):2815–2821

    Article  CAS  Google Scholar 

  25. Ti C-C, Kumar SA, Chen S-M (2009) Electrochemical preparation, characterization, and electrocatalytic studies of Nafion–ruthenium oxide modified glassy carbon electrode. J Solid State Electrochem 13(3):397–406

    Article  CAS  Google Scholar 

  26. Wu Y, Shen Q, Hu S (2006) Direct electrochemistry and electrocatalysis of heme-proteins in regenerated silk fibroin film. Anal Chim Acta 558(1):179–186

    Article  CAS  Google Scholar 

  27. Doménech-Carbó A, Villamón E, Luna I, Ramos D, Doménech-Casasús C, Cebrián-Torrejón G (2016) Transmembrane electrochemistry of erythrocytes: direct electrochemical test for detecting hemolysis in whole blood. Sensors Actuators B Chem 226:419–428

    Article  Google Scholar 

  28. Matysiak E, Donten M, Kowalczyk A, Bystrzejewski M, Grudzinski IP, Nowicka AM (2015) A novel type of electrochemical sensor based on ferromagnetic carbon-encapsulated iron nanoparticles for direct determination of hemoglobin in blood samples. Biosens Bioelectron 64:554–559

    Article  CAS  Google Scholar 

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Funding

The authors acknowledge FAPESP (2017/21097-3, 2017/17572-8, 2019/23177-0, and 2017/21898-6), CAPES, and CNPq (303338/2019-9) for financial support.

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Correspondence to Bruno Campos Janegitz.

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de Oliveira, G.C.M., Camargo, J.R., Vieira, N.C.S. et al. A new disposable electrochemical sensor on medical adhesive tape. J Solid State Electrochem 24, 2271–2278 (2020). https://doi.org/10.1007/s10008-020-04732-w

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  • DOI: https://doi.org/10.1007/s10008-020-04732-w

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