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Study on the Mechanisms of Banxia Xiexin Decoction in Treating Diabetic Gastroparesis Based on Network Pharmacology

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Abstract

In China, Banxia Xiexin decoction (BXD) is applied to treat diabetic gastroparesis (DGP), but its key active ingredients and mechanisms against DGP are unclear. This study is designated to reveal the molecular mechanisms of BXD in treating DGP by adopting a creative approach known as network pharmacology to explore the active ingredients and therapeutic targets of BXD. In our study, 730 differentially expressed genes of DGP were obtained, and 30 potential targets of BXD against DGP were screened out (including ADRB2, DRD1, FOS, MMP9, FOSL1, FOSL2, JUN, MAP2, DRD2, MYC, F3, CDKN1A, IL6, NFKBIA, ICAM1, CCL2, SELE, DUOX2, MGAM, THBD, SERPINE1, ALOX5, CXCL11, CXCL2, CXCL10, RUNX2, CD40LG, C1QB, MCL1, and ADCYAP1). Based on the findings, BXD contains 60 compounds with therapeutic effect on DGP, including the key active ingredients such as quercetin, wogonin, baicalein, beta-sitosterol, and kaempferol. Sixty-eight pathways including TNF signaling pathway, IL-17 signaling pathway, and AGE-RAGE signaling pathway were significantly enriched. In this study, the mechanisms of BXD in treating DGP are affirmed to be a complex network with multi-target and multi-pathway, which provides a reference for future experimental studies.

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Availability of Data and Material

The datasets used and analyzed during the current study are available from the corresponding author on reasonable request.

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Funding

We are grateful for the support from the National Natural Science Foundation of China (Grant No. 81774279) and the Key Research and Development Project of Sichuan Province (Grant No. 2018SZ0068).

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Authors and Affiliations

  1. Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu, 610072, SiChuan, China

    Tingchao Wu, Rensong Yue & Mingmin He

  2. University of Electronic Science and Technology of China, Chengdu, SiChuan, China

    Liang Li

Authors
  1. Tingchao Wu
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  2. Rensong Yue
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  3. Liang Li
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  4. Mingmin He
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Contributions

Tingchao Wu, Rensong Yue, and Liang Li have contributed equally to this work. Tingchao Wu and Rensong Yue designed and drafted the paper. Liang Li and Mingmin He participated in the revision of this article.

Corresponding author

Correspondence to Rensong Yue.

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The authors declare that they have no competing interests.

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All the original data in this article are from the public databases, and this article does not contain any studies with human participants performed by any of the authors.

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Wu, T., Yue, R., Li, L. et al. Study on the Mechanisms of Banxia Xiexin Decoction in Treating Diabetic Gastroparesis Based on Network Pharmacology. Interdiscip Sci Comput Life Sci 12, 487–498 (2020). https://doi.org/10.1007/s12539-020-00389-1

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  • DOI: https://doi.org/10.1007/s12539-020-00389-1

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