Formal Aerobic Oxidative Cross-Coupling of Benzofuranones with Azo Compounds Using Pd-μ-hydroxo Complex

Rikako Ohnishi; Masumi Sugawara; Tetsuya Ezawa; Yoshihiro Sohtome; Mikiko Sodeoka

doi:10.1248/cpb.c20-00359

Notes

Formal Aerobic Oxidative Cross-Coupling of Benzofuranones with Azo Compounds Using Pd-μ-hydroxo Complex

Rikako Ohnishi, Masumi Sugawara, Tetsuya Ezawa, Yoshihiro Sohtome, Mikiko Sodeoka

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Keywords: palladium, molecular oxygen, radical, oxidative cross-coupling

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Supplementary material

2020 Volume 68 Issue 9 Pages 895-898

DOI https://doi.org/10.1248/cpb.c20-00359

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Abstract

We have developed a catalytic aerobic oxidative dimerization reaction of benzofuranones using a Pd(II)-µ-hydroxo complex. Radical-radical cross-coupling of the resulting dimers with azo compounds enabled the one-pot synthesis of structurally congested benzofuranones having two distinct vicinal all-carbon quaternary centers.

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