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Inflammatory effects of particulate matter air pollution

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Abstract

Air pollution is an important cause of non-communicable diseases globally with particulate matter (PM) as one of the main air pollutants. PM is composed of microscopic particles that contain a mixture of chemicals and biological elements that can be harmful to human health. The aerodynamic diameter of PM facilitates their deposition when inhaled. For instance, coarse PM having a diameter of < 10 μm is deposited mainly in the large conducting airways, but PM of < 2.5 μm can cross the alveolar-capillary barrier, traveling to other organs within the body. Epidemiological studies have shown the association between PM exposure and risk of disease, namely those of the respiratory system such as lung cancer, asthma, and chronic obstructive pulmonary disease (COPD). However, cardiovascular and neurological diseases have also been reported, including hypertension, atherosclerosis, acute myocardial infarction, stroke, loss of cognitive function, anxiety, and Parkinson’s and Alzheimer’s diseases. Inflammation is a common hallmark in the pathogenesis of many of these diseases associated with exposure to a variety of air pollutants, including PM. This review focuses on the main effects of PM on human health, with an emphasis on the role of inflammation.

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Acknowledgments

The authors thank the help of Universidad de Antioquia UdeA, Corporacion Universitaria Remington and Universidad Cooperativa de Colombia, for their support in the project.

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This study was financed by Colciencias (141580763047), Universidad Cooperativa de Colombia, and Corporación Universitaria Remington.

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Authors and Affiliations

  1. Grupo de Investigaciones Biomédicas Uniremington, Programa de Medicina, Facultad de Ciencias de la Salud, Corporación Universitaria Remington, Medellín, Colombia

    Rubén D. Arias-Pérez, Natalia A. Taborda & Jazmín Porras

  2. Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia, UdeA, Calle 70 No. 52-21, Medellín, Colombia

    Natalia A. Taborda

  3. Infettare, Facultad de Medicina, Universidad Cooperativa de Colombia, Medellín, Colombia

    Diana M. Gómez & Juan C. Hernandez

  4. Grupo de Investigaciones Ingeniar, Facultad de Ingenierías, Corporación Universitaria Remington, Medellín, Colombia

    Jhon Fredy Narvaez

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Funding acquisition and project administration: JCH. Writing-original draft: RDAP, NAT, DMG, JCH. Writing-review and editing: RDAP, NAT, DMG, JPL, JFN, JCH. Approval of manuscript for publication: RDAP, NAT, DMG, JPL, JFN, JCH.

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Arias-Pérez, R.D., Taborda, N.A., Gómez, D.M. et al. Inflammatory effects of particulate matter air pollution. Environ Sci Pollut Res 27, 42390–42404 (2020). https://doi.org/10.1007/s11356-020-10574-w

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