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Probiotics: a Promising Generation of Heavy Metal Detoxification

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Abstract

Different environmental toxins especially heavy metals exist in soil, water, and air recording toxic effect on human, animal, and plant. These toxicant elements are widespread in environment causing various disturbances in biological systems. Numerous strategies have been applied recently to alleviate heavy metal contamination; however, most of these strategies were costly and seemed unfriendly to our environment. Probiotics are living cell bacteria with beneficial characteristics for human health. Lactobacillus and Bifidobacterium are the major probiotic groups; however, Pediococcus, Lactococcus, Bacillus, and yeasts are recorded as probiotic. The vital role of the probiotics on maintenance of body health was previously investigated. Probiotics were previously recorded to its powerful capacity to bind numerous targets and eliminate them with feces. These targets may be aluminum, cadmium, lead, or arsenic. The current review discusses the history of probiotics, detoxification role of probiotics caused by heavy metals, and mechanism of their action that modulate different signaling pathway disturbance associated with heavy metal accumulation in biological system.

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Abbreviations

A. muciniphila :

Akkermansia muciniphila

EFSA:

European food safety authority

F. prausnitzii :

Faecalibacterium prausnitzii

FAO:

Food and Agriculture Organization

ISAPP:

International Scientific Association of Probiotics and Prebiotics

L. brevis :

Lactobacillus brevis

L. helveticus :

Lactobacillus helveticus

L. plantarum :

Lactobacillus plantarum

L. reuteri :

Lactobacillus reuteri

L. rhamnosus :

Lactobacillus rhamnosus

WHO:

World Health Organization

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  1. Therapeutic Chemistry Department, National Research Centre, El-Buhouth St, Dokki, Cairo, 12622, Egypt

    Rehab M. Abdel-Megeed

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Abdel-Megeed, R.M. Probiotics: a Promising Generation of Heavy Metal Detoxification. Biol Trace Elem Res 199, 2406–2413 (2021). https://doi.org/10.1007/s12011-020-02350-1

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