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Effects of Nano-copper on Antioxidant Function in Copper-Deprived Guizhou Black Goats

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Abstract

Guizhou black goats are essential to the production system in the Wumeng prairie in the Western China. This study aimed to determine the influence of nano-copper on antioxidant system in copper-deprived Guizhou black goats. We analyzed mineral contents in soil, forage, and goats’ tissues. Blood parameters were also determined. The results showed that copper concentrations in soil and forage were significantly lower, and the iron content was significantly higher in affected compared with healthy area (P < 0.01). Copper concentrations in animal tissues (blood, liver, and hair) were significantly lower and iron content was significantly higher in affected compared with healthy goats (P < 0.01). After supplementation of nano-copper or copper sulfate, copper concentration in blood was significantly increased and iron content was significantly lower (P < 0.01). Compared with nano-copper group, the effect of copper sulfate was slower. Hemoglobin levels, erythrocyte count, and packed cell volume from nano-copper and copper sulfate groups were significantly higher than those in copper-deprived goats (P < 0.01). Compared with the copper-deprived Guizhou black goats, serum ceruloplasmin levels in nano-copper and copper sulfate groups were significantly increased, while serum lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and creatinine were significantly decreased (P < 0.01). Compared with the copper-deprived animals, serum superoxide dismutase, glutathione peroxidase, catalase, and total antioxidant capacity in nano-copper and copper sulfate groups were significantly higher, while serum malondialdehyde content was significantly lower (P < 0.01). The effect of copper sulfate group was significantly lower than that in nano-copper group (P < 0.01). Consequently, nano-copper could not only markedly increase the copper content in blood in copper-deprived Guizhou black goats but also much improves the antioxidant capacity.

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Funding

This work was supported by the Project of National Key Research and Development Program of China in 13th Five-year Plan (2016YFC0502601) and the National Natural Science Foundation of China (41671041).

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Authors and Affiliations

  1. School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang, 621010, China

    Xiaoyun Shen, Chunjie Song & Ting Wu

  2. State Engineering Technology Institute for Karst Desertification Control, Guizhou Normal University, Guiyang, 550025, China

    Xiaoyun Shen

  3. World Bank Poverty Alleviation Project Office in Guizhou, Southwest China, Guiyang, 550004, China

    Xiaoyun Shen

Authors
  1. Xiaoyun Shen
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  3. Ting Wu
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Correspondence to Xiaoyun Shen.

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Ethics statement

The Guizhou black goats that were used in this study were cared for as outlined in the Guide for the Care and Use of Animals in Agricultural Research and Teaching Consortium (Federation of Animals Science Societies, 2016). Sample collections from goats were approved by Southwest University of Science and Technology in China, Institutional Animal Care and Use Committee (Project A00657).

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Xiaoyun Shen and Chunjie Song Equal contributors, they are co-first authors.

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Shen, X., Song, C. & Wu, T. Effects of Nano-copper on Antioxidant Function in Copper-Deprived Guizhou Black Goats. Biol Trace Elem Res 199, 2201–2207 (2021). https://doi.org/10.1007/s12011-020-02342-1

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