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Evaluation of the Effect of Plasma from Patients with Trophic Ulcers on the Function of Dermal Fibroblasts, Mesenchymal Stem Cells, and Endothelial Cells

  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effect of platelet lysate and platelet-poor plasma from patients with trophic ulcers with and without type 2 diabetes mellitus on proliferation, migration, and apoptosis of human dermal fibroblast, mesenchymal stem cells, and endothelial cells. It is shown that plasma obtained from patients with type 2 diabetes mellitus produced inhibitory effects.

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Authors and Affiliations

  1. Research Institute of Clinical and Experimental Lymphology — Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    A. P. Lykov, M. A. Surovtseva, O. V. Poveshchenko, N. A. Bondarenko, I. I. Kim & E. V. Yankaite

  2. E. N. Meshalkin National Medical Research Center, Ministry of Health of Russian Federation, Novosibirsk, Russia

    A. P. Lykov, M. A. Surovtseva, O. V. Poveshchenko, N. A. Bondarenko & I. I. Kim

Authors
  1. A. P. Lykov
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  2. M. A. Surovtseva
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  3. O. V. Poveshchenko
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  4. N. A. Bondarenko
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  5. I. I. Kim
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  6. E. V. Yankaite
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Correspondence to A. P. Lykov.

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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 2, pp. 98-19, June, 2020

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Lykov, A.P., Surovtseva, M.A., Poveshchenko, O.V. et al. Evaluation of the Effect of Plasma from Patients with Trophic Ulcers on the Function of Dermal Fibroblasts, Mesenchymal Stem Cells, and Endothelial Cells. Bull Exp Biol Med 169, 558–563 (2020). https://doi.org/10.1007/s10517-020-04929-z

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  • DOI: https://doi.org/10.1007/s10517-020-04929-z

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