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Multi-ligament reconstructions as a risk factor for adverse outcomes in arthroscopic surgery

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Knee Surgery, Sports Traumatology, Arthroscopy Aims and scope

Abstract

Purpose

Multi-ligament knee injuries are a serious consequence of knee dislocation with a poorly evaluated post-operative complication profile due to low incidence. The aim of this study is to assess the risk of adverse post-operative events associated with operative management of multi-ligament knee injuries.

Methods

The American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database was used to identify patients undergoing surgical procedures for multi-ligament knee injuries from 2006 to 2016 using Current Procedural Terminology codes. We evaluated data on patient demographics and used a propensity score algorithm to adjust for baseline differences in these patients and developed univariate and multivariate logistic regression models to assess effects on minor and severe 30-day post-operative complications.

Results

We identified 444 patients in this database who underwent multi-ligament knee reconstructions between 2006 and 2016. After propensity matching, minor and major adverse post-operative events were more frequent in patients with multi-ligament knee injuries (1.4% vs 0.2%, p < 0.001 and 2.7% vs 1.1%, p = 0.002, respectively). Patients with multi-ligament knee injuries experienced a 55-fold increase risk of need for transfusion (p < 0.001) and a fivefold increased risk of pulmonary embolism (p = 0.025), with most occurring in bicruciate reconstructions (Schenck Classification KD-III and KD-IV injuries).

Conclusion

The surgical management of multi-ligament knee injuries confers significant increased risk of 30-day post-operative minor or severe adverse event over arthroscopic ACL reconstruction. These patients are most at risk for post-operative blood transfusion requirement, and pulmonary embolism, with patient’s undergoing surgery for bicruciate ligament injuries at particularly high risk of complication.

Level of evidence

IV.

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References

  1. Alentorn-Geli E, Lazarides AL, Utturkar GM, Myers HS, Samuelsson K, Choi JHJ et al (2019) Factors predictive of poorer outcomes in the surgical repair of multiligamentous knee injuries. Knee Surg Sports Traumatol Arthrosc. 27(2):445–459

    PubMed  Google Scholar 

  2. American College of Surgeons National Surgical Quality Improvement Program. User guide for the 2016 participant use data file. https://acsnsqip.org/main/programspecs/program_data_collection.jsp. Accessed 21 Jan 2019

  3. Arom GA, Yeranosian MG, Petrigliano FA, Terrell RD, McAllister DR (2014) The changing demographics of knee dislocation: a retrospective database review. Clin Orthop Relat Res 472(9):2609–2614

    PubMed  Google Scholar 

  4. Azar FM, Brandt JC, Miller RH, Phillips BB (2011) Ultra-low velocity knee dislocations. Am J Sports Med 39(10):2170–2174

    PubMed  Google Scholar 

  5. Bedard NA, DeMik DE, Owens JM, Glass NA, DeBerg J, Callaghan JJ (2019) Tobacco use and risk of wound complications and periprosthetic joint infection; a systematic review and meta-analysis of primary total joint arthroplasty procedures. J Arthroplasty 34(2):385–396

    PubMed  Google Scholar 

  6. Born TR, Engasser WM, King AH, Krych AJ, Dahm DL, Levy BA et al (2014) Low frequency of symptomatic venous thromboembolism after multiligamenous knee reconstruction with thromboprophylaxis. Clin Orthop Relat Res 472(9):2705–2711

    PubMed  PubMed Central  Google Scholar 

  7. Burrus MT, Werner BC, Griffin JW, Gwathmey FW, Miller MD (2016) Diagnostic and management strategies for multiligament knee injuries: a critical analysis review. JBJS Rev 4(2):1–9

    Google Scholar 

  8. Castillo RC, Bosse MJ, MacKenzie EJ, Patterson BM, Group LS (2005) Impact of smoking on fracture healing and risk of complications in limb-threatening open tibia fractures. J Orthop Trauma 19:151–157

    PubMed  Google Scholar 

  9. Cook S, Ridley TJ, McCarthy M, Gao Y, Wolf BR, Amendola A et al (2015) Surgical treatment of multiligament knee injuries. Knee Surg Sports Traumatol Arthrosc 23:2983–2991

    PubMed  Google Scholar 

  10. Cvetanovich GL, Chalmers PN, Verma NN, Cole BJ, Bach BR Jr (2016) Risk factors for short-term complications of anterior cruciate ligament reconstruction in the United States. Am J Sports Med 44:618–624

    PubMed  Google Scholar 

  11. Dedmond BT, Almekinders LC (2001) Operative versus nonoperative treatment of knee dislocations: a meta-analysis. Am J Knee Surg 14:33–38

    CAS  PubMed  Google Scholar 

  12. Engebretsen L, Risberg MA, Robertson B, Ludvigsen TC, Johansen S (2009) Outcome after knee dislocation: a 2–9 years follow-up of 85 consecutive patients. Knee Surg Sports Traumatol Arthrosc 17(9):1013–1026

    PubMed  Google Scholar 

  13. Epelboym I, Gawlas I, Lee JA, Schrope B, Chabot JA, Allendorf JD (2014) Limitations of ACS-NSQIP in reporting complications for patients undergoing pancreatectomy: underscoring the need for a pancreas-specific module. World J Surg 38(6):1461–1467

    PubMed  Google Scholar 

  14. Fanelli GC, Orcutt DR, Edson CJ (2005) The multiple-ligament injured knee: evaluation, treatment, and results. Arthroscopy 21:471–486

    PubMed  Google Scholar 

  15. Fanelli GC, Stannard JP, Stuart MJ, MacDonald PB, Marx RG, Whelan DB et al (2010) Management of complex knee ligament injuries. J Bone Joint Surg Am 92:2235–2246

    PubMed  Google Scholar 

  16. Frick WG, Seals RR Jr (1994) Smoking and wound healing: a review. Tex Dent J 111:21–23

    CAS  PubMed  Google Scholar 

  17. Glassman SD, Anagnost SC, Parker A, Burke D, Johnson JR, Dimar JR (2000) The effect of cigarette smoking and smoking cessation on spinal fusion. Spine (Phila Pa 1976) 25:2608–2615

    CAS  Google Scholar 

  18. Hatch GFR 3rd, Villacis D, Damodar D, Dacey M, Yi A (2018) Quality of life and functional outcomes after multiligament knee reconstruction. J Knee Surg 10:970–978

    Google Scholar 

  19. Henruchs A (2004) A review of knee dislocations. J Athl Train 39:365–369

    Google Scholar 

  20. Januel JM, Chen G, Ruffieux C, Quan H, Douketis JD, Crowther, et al (2012) Symptomatic in-hospital deep vein thrombosis and pulmonary emobolism following hip and knee arthroplasty among patients receiving recommended prophylaxis: a systematic review. JAMA 307(3):294–303

    CAS  PubMed  Google Scholar 

  21. Kennedy JC (1963) Complete dislocation of the knee joint. J Bone Joint Surg Am 45:889–904

    CAS  PubMed  Google Scholar 

  22. King AH, Krych AJ, Prince MR, Pareek A, Stuart MJ, Levy BA (2016) Surgical outcomes of medial versus lateral multiligament-injured, dislocated knees. Arthroscopy 32(9):1814–1819

    PubMed  Google Scholar 

  23. Kraus Schmitz J, Lindgren V, Janary PM, Forssblad M, Stalman A (2019) Deep venous thrombosis and pulmonary embolism after anterior cruciate ligament reconstruction. Bone Joint J. 101-B(1):34–40

    CAS  PubMed  Google Scholar 

  24. Levy BA, Dajani KA, Whelan DB, Stannard JP, Fanelli GC, Stuart MJ et al (2009) Decision making in the multiligament-injured knee; an evidence-based systematic review. Arthroscopy 25:430–438

    PubMed  Google Scholar 

  25. Levy BA, Fanelli GC, Whelan DB, Stannard JP, MacDonald PA, Boyd JL et al (2009) Controversies in the treatment of knee dislocations and multiligament reconstruction. J Am Acad Orthop Surg 17:197–206

    PubMed  Google Scholar 

  26. Lindstrom D, Sadr Azodi O, Wladis A et al (2008) Effects of a perioperative smoking cessation intervention on postoperative complications: a randomized trial. Ann Surg 248:739–745

    PubMed  Google Scholar 

  27. Manske RC, Hossenzadeh P, Giangarra CE (2008) Multiple ligament knee injury: complicaitons. N Am J Sports Phys Ther 3(4):226–233

    PubMed  PubMed Central  Google Scholar 

  28. Moatshe G, Chahla J, LaPrade RF, Engebretsen L (2017) Diagnosis and treatment of multiligament knee injury: state of the art. JISAKOS 2:152–161

    Google Scholar 

  29. Moller AM, Villebro N, Pedersen T, Tonnesen H (2002) Effect of preoperative smoking intervention on postoperative complications: a randomised clinical trial. Lancet 359:114–117

    PubMed  Google Scholar 

  30. Natsuhara KM, Yeranosian MG, Cohen JR, Wang JC, McAllister DR, Petrigliano FA (2014) What is the frequency of vascular injury after knee dislocation? Clin Orthop Relat Res 472(9):2615–2620

    PubMed  PubMed Central  Google Scholar 

  31. Palazzola A, Rosso F, Bonasia DE, Saccia F, Rossi R (2018) Uncommon complications after anterior cruciate ligament reconstruction. Joints 6(3):188–203

    Google Scholar 

  32. Peskun CJ, Whelan DB (2011) Outcomes of operative and nonoperative treatment of multiligament knee injuries: an evidence-based review. Sports Med Arthrosc Rev 19(2):167–173

    PubMed  Google Scholar 

  33. Richter M, Bosch U, Wippermann B, Hofmann A, Krettek C (2002) Comparison of surgical repair or reconstruction of the cruciate ligaments versus nonsurgical treatment in patients with traumatic knee dislocations. Am J Sports Med 30:718–727

    PubMed  Google Scholar 

  34. Ridley TJ, Cook S, Bollier M, McCarthy M, Wolf B, Amendola A (2014) Effect of body mass index on patients with multiligamentous knee injuries. Arthroscopy 30(11):1447–1452

    CAS  PubMed  Google Scholar 

  35. Shiloach M, Frencher SK Jr, Steeger JE et al (2010) Toward robust information: data quality and inter-rater reliability in the American College of Surgeons National Surgical Quality Improvement Program. J Am Coll Surg 210:6–16

    PubMed  Google Scholar 

  36. Silverstein P (1992) Smoking and wound healing. Am J Med 93:22S–S24

    CAS  PubMed  Google Scholar 

  37. Stannard JP, Bauer KL (2012) Current concepts in knee dislocations: PCL, ACL, and medial sided injuries. J Knee Surg 25:287–294

    PubMed  Google Scholar 

  38. Stukel TA, Fisher ES, Wennberg DE, Alter DA, Gottlieb DJ, Vermeulen MJ (2007) Analysis of observational studies in the presence of treatment selection bias: effects of invasive cardiac management on AMI survival using propensity score and instrumental variable methods. JAMA 2297(3):278–285

    Google Scholar 

  39. Tardy N, Boisrenoult P, Teissier P, Steltzlen C, Beaufils P, Pujol N (2017) Clinical outcomes after multiligament injured knees: medial versus lateral reconstructions. Knee Surg Sports Traumatol Arthrosc 25:524–531

    CAS  PubMed  Google Scholar 

  40. Werier J, Keating JF, Meek RN (1998) Complete dislocation of the knee—the long-term results of ligamentous reconstruction. Knee 5:255–260

    Google Scholar 

  41. Werner BC, Gwathmey FW Jr, Higgins ST, Hart JM, Miller MD (2013) Ultra-low velocity knee dislocations: patient characteristics, complications, and outcomes. Am J Sports Med 42(2):358–363

    PubMed  Google Scholar 

  42. Worley JR, Brimmo O, Nuelle CW, Cook JL, Stannard JP (2019) Incidence of concurrent peroneal nerve injury in multiligament knee injuries and outcomes after knee reconstruction. J Knee Surg 32(6):560–564

    PubMed  Google Scholar 

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Correspondence to Vehniah Tjong.

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Kyhos, J., Johnson, D., Alvandi, B. et al. Multi-ligament reconstructions as a risk factor for adverse outcomes in arthroscopic surgery. Knee Surg Sports Traumatol Arthrosc 29, 1913–1919 (2021). https://doi.org/10.1007/s00167-020-06252-6

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  • DOI: https://doi.org/10.1007/s00167-020-06252-6

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