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Biogenic Synthesis of Rod Shaped ZnO Nanoparticles Using Red Paprika (Capsicum annuum L. var. grossum (L.) Sendt) and Their in Vitro Evaluation

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Abstract

Metal oxide nanoparticles (NPs) have gained attention in biomedicine due to their broad spectrum of applications, such as targeted drug delivery, their use as antibacterial agents or in cancer treatments. In particular, zinc oxide nanoparticles (ZnO NPs) have become one of the most popular metal oxide NPs in biomedical applications. The present study describes for the first time the biogenic synthesis of rod shaped ZnO NPs using C. annuum L. var. grossum (L.) Sendt) extract as a capping agent. The purified C. annum-based zinc oxide nanorods (Ca-ZnO NRs) were characterized by different physico-chemical techniques. UV–vis spectroscopy depicted the absorbance peak at 372 nm. The size of nanorods ranges between 70 and 80 nm as revealed by FE-TEM micrographs and the mean size was 72 nm. Ca-ZnO NRs exhibited antibacterial activity in a dose-dependent manner and a greater activity was observed against S. enterica. Ca-ZnO NRs have shown antioxidant activity (91%) at 100 μg ml−1 when compared to the standard (ascorbic acid) (98%). A significant inhibition of bovine serum albumin (BSA) protein denaturation evidenced their anti-inflammatory property. Further, Ca-ZnO NRs showed hemolysis of red blood cells (RBC) (~ 3%) (up to 3 μg ml−1) which is much lesser than permissible limit.

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Acknowledgement

This work was supported by Ministry of Agriculture Food and rural Affairs (318077-2). The author KS thanks the Korea Research Fellowship (KRF) Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT (2017H1D3A1A01052610). Prof. Esteban F. Durán-Lara thanks the FONDECYT projects number 11170155. The authors SV, MD and BV thank the RUSA phase 2.0 grant [Ref 24-51-2014-U-policy] TN Multi-Gen. Department of Education, Government of India.

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Authors and Affiliations

  1. Department of Medical Biotechnology, College of Biomedical Sciences, Kangwon National University, Chuncheon, Gangwon-do, 24341, Republic of Korea

    Sekar Vijayakumar, Kandasamy Saravanakumar & Myeong-Hyeon Wang

  2. Nanobiosciences and Nanopharmacology Division, Biomaterials and Biotechnology in Animal Health Lab, Department of Animal Health and Management, Science Campus 6th Floor, Alagappa University, Karaikudi, 630004, Tamil Nadu, India

    Sekar Vijayakumar, Mani Divya & Baskaralingam Vaseeharan

  3. Nanobiology Laboratory, Department of Natural and Exact Sciences, Pontificia Universidad Católica Madre y Maestra, PUCMM, Autopista Duarte Km 1½, Santiago de los Caballeros, Dominican Republic

    Zaira I. González-Sánchez

  4. Department of Biology, The Gandhigram Rural Institute (Deemed to be University), Dindigul District, Gandhigram, Tamil Nadu, 624 302, India

    Balasubramanian Malaikozhundan

  5. Bio & NanoMaterials Lab| Drug Delivery and Controlled Release, Universidad de Talca, 3460000, Talca, Maule, Chile

    Esteban F. Durán-Lara

  6. Departamento de Microbiología, Facultad de Ciencias de la Salud, Universidad de Talca, 3460000, Talca, Maule, Chile

    Esteban F. Durán-Lara

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  1. Sekar Vijayakumar
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Correspondence to Sekar Vijayakumar or Myeong-Hyeon Wang.

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Vijayakumar, S., González-Sánchez, Z.I., Malaikozhundan, B. et al. Biogenic Synthesis of Rod Shaped ZnO Nanoparticles Using Red Paprika (Capsicum annuum L. var. grossum (L.) Sendt) and Their in Vitro Evaluation. J Clust Sci 32, 1129–1139 (2021). https://doi.org/10.1007/s10876-020-01870-z

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