Skip to main content

Advertisement

Log in

Hydrocephalus secondary to dengue encephalitis in an infant: case report

  • Case Report
  • Published:
Child's Nervous System Aims and scope Submit manuscript

Abstract

Background

Dengue is the leading cause of mosquito-borne viral infection. It is responsible for high morbidity and mortality in children living in endemic areas. Nowadays, neurological complications are progressively referred to and include a broad spectrum of symptoms. It can be secondary to metabolic alterations, direct invasion by the virus, and enhanced autoimmune response.

Case presentation

Here, we report a rare case of hydrocephalus secondary to dengue encephalitis. A 13-day-old boy was diagnosed with dengue. He evolved with seizures and impaired consciousness being diagnosed with encephalitis. After clinical treatment, he was discharged fully recovered. Three months later, he presented with signs and symptoms of intracranial hypertension. Brain MRI revealed hydrocephalus secondary to acquired aqueduct stenosis. The patient underwent an endoscopic third ventriculocisternostomy.

Conclusion

Dengue infection is a differential diagnosis for acute febrile neurological impairment in children from endemic areas. Follow-up should be offered after dengue encephalitis to detect possible late-onset complications, as hydrocephalus.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

Data availability

Not applicable.

References

  1. Murray NEA, Quam MB, Wilder-Smith A (2013) Epidemiology of dengue: past, present and future prospects. Clin Epidemiol 5:299–309. https://doi.org/10.2147/CLEP.S34440

    Article  PubMed  PubMed Central  Google Scholar 

  2. World Health Organization (2012) Global strategy for dengue prevention and control, 2012–2020

  3. Verma R, Sahu R, Holla V (2014) Neurological manifestations of dengue infection: a review. J Neurol Sci 346:26–34. https://doi.org/10.1016/j.jns.2014.08.044

    Article  PubMed  Google Scholar 

  4. World Health Organization (2009) Dengue guidelines for diagnosis, treatment, prevention and control: new edition

  5. Li G-H, Ning Z-J, Liu Y-M, Li X-H (2017) Neurological manifestations of dengue infection. Front Cell Infect Microbiol 7:1–17. https://doi.org/10.3389/fcimb.2017.00449

    Article  Google Scholar 

  6. Carod-Artal FJ, Wichmann O, Farrar J, Gascón J (2013) Neurological complications of dengue virus infection. Lancet Neurol 12:906–919. https://doi.org/10.1016/S1474-4422(13)70150-9

    Article  PubMed  Google Scholar 

  7. Murthy JMK (2010) Neurological complication of dengue infection. Neurol India 58:581–584. https://doi.org/10.4103/0028-3886.68654

    Article  CAS  PubMed  Google Scholar 

  8. Brito Ferreira ML, Gomes Cavalcanti C, Alvarenga Coelho C, Dornelas Mesquita S (2005) Neurological manifestations of dengue: study of 41 cases. Arq Neuropsiquiatr 63:488–493

    Article  Google Scholar 

  9. Puccioni-Sohler M, Rosadas C, Cabral-Castro MJ (2013) Neurological complications in dengue infection: a review for clinical practice. Arq Neuropsiquiatr 71:667–671. https://doi.org/10.1590/0004-282X20130147

    Article  PubMed  Google Scholar 

  10. Arishi HM, Ageel AA, Al Najmi MI et al (2020) Dengue meningoencephalitis in a child presenting with focal seizures. Int J Pediatr Adolesc Med 355:1053–1059. https://doi.org/10.1016/j.ijpam.2020.01.007

    Article  Google Scholar 

  11. Cam B, Fonsmark L, Hue N et al (2001) Prospective case control study of encephalopathy in children with dengue hemorrhagic fever. Am J Trop Med Hyg 65:848–851

    Article  CAS  Google Scholar 

  12. Domingues RB, Kuster GW, Onuki-Castro FL et al (2008) Involvement of the central nervous system in patients with dengue virus infection. J Neurol Sci 267:36–40. https://doi.org/10.1016/j.jns.2007.09.040

    Article  PubMed  Google Scholar 

  13. Osnaya-Romero N, Perez-Guille MG, Andrade-García S et al (2017) Neurological complications and death in children with dengue virus infection: report of two cases. J Venom Anim Toxins Incl Trop Dis 23:25. https://doi.org/10.1186/s40409-017-0115-x

    Article  PubMed  PubMed Central  Google Scholar 

  14. Miagostovich MP, Ramos RG, Nicol AF, Nogueira RM, Cuzzi-Maya T, Oliveira AV, Marchevsky RS, Mesquita RP, Schatzmayr HG (1997) Retrospective study on dengue fatal cases. Clin Neuropathol 16:204–208

    CAS  PubMed  Google Scholar 

  15. Solomon T, Dung NM, Vaughn DW et al (2000) Neurological manifestations of dengue infection. Lancet 355:1053–1059. https://doi.org/10.1016/S0140-6736(00)02036-5

    Article  CAS  PubMed  Google Scholar 

  16. Kamble RB, Venkataramana NK, Raghunath CN (2011) Dengue encephalitis associated with hydrocephalus: a case report. Neuroradiol J 24:833–837. https://doi.org/10.1177/197140091102400601

    Article  CAS  PubMed  Google Scholar 

  17. Poletti M, Sousa C, Sampaio M (2016) Evidencias de transmisión vertical de arbovirus. Residência Pediátrica 6:21–24. https://doi.org/10.25060/residpediatr-2016.v6n1-04

    Article  Google Scholar 

  18. Jain A, Chaturvedi UC (2010) Dengue in infants: an overview. FEMS Immunol Med Microbiol 59:119–130. https://doi.org/10.1111/j.1574-695X.2010.00670.x

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Varatharaj A (2010) Encephalitis in the clinical spectrum of dengue infection. Neurol India 58:585–591. https://doi.org/10.4103/0028-3886.68655

    Article  PubMed  Google Scholar 

  20. Soares C, Puccioni-Sohler M (2014) Diagnosis criteria of dengue encephalitis. Arq Neuropsiquiatr 72:263. https://doi.org/10.1590/0004-282X20130251

    Article  Google Scholar 

  21. Araújo F, Nogueira R, Araújo M d S et al (2012) Dengue in patients with central nervous system manifestations, Brazil. Emerg Infect Dis 18:677–679. https://doi.org/10.3201/eid1804.111552

    Article  PubMed  PubMed Central  Google Scholar 

  22. Hegde V, Aziz Z, Kumar S et al (2015) Dengue encephalitis with predominant cerebellar involvement: report of eight cases with MR and CT imaging features. Eur Radiol 25:719–725. https://doi.org/10.1007/s00330-014-3473-6

    Article  PubMed  Google Scholar 

  23. Wasay M, Channa R, Jumani M et al (2008) Encephalitis and myelitis associated with dengue viral infection. Clinical and neuroimaging features. Clin Neurol Neurosurg 110:635–640. https://doi.org/10.1016/j.clineuro.2008.03.011

    Article  PubMed  Google Scholar 

  24. Bhoi SK, Naik S, Kumar S et al (2014) Cranial imaging findings in dengue virus infection. J Neurol Sci 342:36–41. https://doi.org/10.1016/j.jns.2014.04.018

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Bárbara Albuquerque Morais.

Ethics declarations

Conflict of interest

The authors declare that there is no conflict of interest.

Code availability

Not applicable.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Morais, B.A., Pereira, N.M., Franco, C.L. et al. Hydrocephalus secondary to dengue encephalitis in an infant: case report. Childs Nerv Syst 37, 2357–2361 (2021). https://doi.org/10.1007/s00381-020-04876-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00381-020-04876-0

Keywords

Navigation