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SYNTHESIS, CRYSTAL STRUCTURE, AND ANTI-GASTRIC CANCER ACTIVITY OF A Zn(II) COORDINATION POLYMER WITH A 4,4′-BIS(1-IMIDAZOLYL)BIPHENYL LIGAND

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Abstract

In this work, the rod-like 4,4′-bis(imidazol-1-yl)-biphenyl (bibp) ligand is utilized as a building block for the coordination assembly with the Zn(II) ion to produce a new Zn(II)-based coordination polymer [Zn3(bibp)2(HCOO)6](H2O)2 (1) under solvothermal conditions. Furthermore, we use the grinding method to downsize complex 1 to the nanoregion. The anti-gastric cancer activity of the compound is evaluated by the Annexin V-FITC/PI apoptosis assay in flow cytometry, and the following mechanism exploration is performed by the DCFH-DA detection assay for the ROS detection.

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Funding

This work was supported financially by Project of Major Science and Technology in Inner Mongolia (2019ZD006) and Transformation Project of scientific and technological achievements in Inner Mongolia (CGZH2018157).

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Authors and Affiliations

  1. Brucellosis Prevention and Treatment Engineering Research Center of Inner Mongolia Autonomous Region, Tongliao, Inner Mongolia, P. R. China

    J B Zhai

  2. Medical College of Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, P. R. China

    J B Zhai

  3. Department of Medicine, Jinan People′s Hospital, Jinan, Shandong, P. R. China

    L H Jiang

  4. Department of Medicine, People′s Hospital of Hangzhou, Hangzhou, Zhejiang, P. R. China

    Y Jiang

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  1. J B Zhai
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  2. L H Jiang
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Correspondence to J B Zhai.

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Zhai, J.B., Jiang, L.H. & Jiang, Y. SYNTHESIS, CRYSTAL STRUCTURE, AND ANTI-GASTRIC CANCER ACTIVITY OF A Zn(II) COORDINATION POLYMER WITH A 4,4′-BIS(1-IMIDAZOLYL)BIPHENYL LIGAND. J Struct Chem 61, 1103–1110 (2020). https://doi.org/10.1134/S0022476620070136

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  • DOI: https://doi.org/10.1134/S0022476620070136

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