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CRYSTAL STRUCTURE AND ANTI-LIVER CANCER ACTIVITY OF A NEW TETRANUCLEAR Zn COMPLEX WITH 2-ETHOXY-6-METHYLIMINOMETHYL-PHENOL

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Abstract

A new metal coordination complex [Zn(L)(N3)]4 (1) based on the Schiff base ligand 2-ethoxy-6-methyliminomethyl-phenol (HL) is successfully prepared via a slow evaporation method. The as-prepared metal complex is characterized by various physicochemical techniques, e.g. elemental analysis and X-ray single crystal diffraction. Furthermore, we use a mechanical grinding method to prepare nanosized crystalline complex 1 (nano-1). The anti-liver cancer activity of nano-1 is evaluated in vitro. Firstly, the cell viability and cell proliferation ability are assessed with CCK-8 and cell colony formation assay, respectively. In addition to this, the cell migration and invasion are also evaluated with the transwell assay after indicated treatment.

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Authors and Affiliations

  1. Department of Infectious Diseases, Linyi Central Hospital, Linyi, Shandong, P. R. China

    Y Li, X Wang, J Zhang, C Lu, S Chen & C Wu

  2. Department of Surgery, Huai′an People′s Hospital, Huai′an, Jiangsu, P. R. China

    X C Zhu & F Han

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  1. Y Li
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  2. X Wang
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  3. J Zhang
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  4. C Lu
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  5. S Chen
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  6. C Wu
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  7. X C Zhu
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  8. F Han
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Correspondence to C Wu.

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Li, Y., Wang, X., Zhang, J. et al. CRYSTAL STRUCTURE AND ANTI-LIVER CANCER ACTIVITY OF A NEW TETRANUCLEAR Zn COMPLEX WITH 2-ETHOXY-6-METHYLIMINOMETHYL-PHENOL. J Struct Chem 61, 1117–1123 (2020). https://doi.org/10.1134/S002247662007015X

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  • DOI: https://doi.org/10.1134/S002247662007015X

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