Issue 22, 2020

A practical pH-compatible fluorescent sensor for hydrazine in soil, water and living cells

Abstract

The excellent water solubility of hydrazine (N2H4) allows it to easily invade the human body through the skin and respiratory tract, thereby damaging human organs and the central nervous system. To realize the monitoring of N2H4 effectively, first, coumarin was used to construct an inner alicyclic ring as the reaction site, extending the conjugation and strengthening the rigidity of the probe Co-Hy to improve its luminescence performance and enhance its ability to resist acids and alkalis. Second, we introduced a carboxyl group at the ortho position of the inner alicyclic ring to improve the water solubility of Co-Hy, and its strong electron pulling effect increased the activity of the reaction site. Spectroscopy experiments showed that Co-Hy featured excellent water solubility, high pH resistance (pH 4–11), excellent selectivity, fast analysis speed (within 5 minutes), and a low detection limit toward N2H4 (69 nM, 2.2 ppb). In addition, test-strip, spray, and cell-imaging experiments confirmed the outstanding application potential of Co-Hy for convenient N2H4 analysis in a variety of environments.

Graphical abstract: A practical pH-compatible fluorescent sensor for hydrazine in soil, water and living cells

Supplementary files

Article information

Article type
Paper
Submitted
13 Aug 2020
Accepted
26 Aug 2020
First published
03 Sep 2020

Analyst, 2020,145, 7380-7387

A practical pH-compatible fluorescent sensor for hydrazine in soil, water and living cells

H. Yan, F. Huo, Y. Yue, J. Chao and C. Yin, Analyst, 2020, 145, 7380 DOI: 10.1039/D0AN01633K

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