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Usefulness of texture analysis for grading pancreatic neuroendocrine tumors on contrast-enhanced computed tomography and apparent diffusion coefficient maps

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Abstract

Purpose

To determine whether texture analysis of contrast-enhanced computed tomography (CECT) and apparent diffusion coefficient (ADC) maps could predict tumor grade (G1 vs G2–3) in patients with pancreatic neuroendocrine tumor (PNET).

Materials and methods

Thirty-three PNETs (22 G1 and 11 G2–3) were retrospectively reviewed. Fifty features were individually extracted from the arterial and portal venous phases of CECT and ADC maps by two radiologists. Diagnostic performance was assessed by receiver operating characteristic curves while inter-observer agreement was determined by calculating intraclass correlation coefficients (ICCs).

Results

G2–G3 tumors were significantly larger than G1. Seventeen features significantly differed among the two readers on univariate analysis, with ICCs > 0.6; the largest area under the curve (AUC) for features of each CECT phase and ADC map was log-sigma 1.0 joint-energy = 0.855 for the arterial phase, log-sigma 1.5 kurtosis = 0.860 for the portal venous phase, and log-sigma 1.0 correlation = 0.847 for the ADC map. The log-sigma 1.5 kurtosis of the portal venous phase showed the largest AUC in the CECT and ADC map, and its sensitivity, specificity, and accuracy were 95.5%, 72.7%, and 87.9%, respectively.

Conclusion

Texture analysis may aid in differentiating between G1 and G2–3 PNET.

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Acknowledgements

The authors would like to thank Soumei Nozu (Siemens Japan K. K., Customer Service Division) for providing information about detailed MR parameters.

Funding

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Radiology, The Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi, Minato-ku, Tokyo, Japan

    Kazuyoshi Ohki, Takao Igarashi, Hirokazu Ashida, Shinsuke Takenaga, Megumi Shiraishi, Yosuke Nozawa & Hiroya Ojiri

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  1. Kazuyoshi Ohki
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  2. Takao Igarashi
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  3. Hirokazu Ashida
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  4. Shinsuke Takenaga
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Correspondence to Kazuyoshi Ohki.

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Ohki, K., Igarashi, T., Ashida, H. et al. Usefulness of texture analysis for grading pancreatic neuroendocrine tumors on contrast-enhanced computed tomography and apparent diffusion coefficient maps. Jpn J Radiol 39, 66–75 (2021). https://doi.org/10.1007/s11604-020-01038-9

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  • DOI: https://doi.org/10.1007/s11604-020-01038-9

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