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Electrospun Poly(ε-caprolactone)/Gelatin Nanofibrous Mat Containing Selenium as a Potential Wound Dressing Material: In Vitro and In Vivo Study

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Abstract

In the current study, selenium particles were loaded into poly(ε-caprolactone)/gelatin nanofibrous matrices in order to fabricate a potential wound dressing. The mats were produced by electrospinning of poly(ε-caprolactone)/Gelatin (1:1 (w/w)) solution supplemented with 1 and 10 % (w/v) of selenium particles. Prepared wound dressings were investigated regarding their morphology, mechanical properties, surface wettability, water-uptake capacity, water vapor permeability, porosity, blood compatibility, microbial penetration test and cellular response. Dressings containing 1 % and 10 % selenium and selenium free mats were chosen to treat the full-thickness excisional wounds in Wistar rats. The study revealed that after 14 days, the wound closure of the mat containing 1 % selenium was about 95.5±6.38 % while wound closure of the negative control group was about 48.83±4.03 %. Our results showed the capability of nanofibrous containing selenium for successful wound treatment.

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Author notes

  1. These authors contribute equally to this work.

Authors and Affiliations

  1. Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahroud, 3614773955, Iran

    Majid Salehi

  2. Tissue Engineering and Stem Cells Research Center, Shahroud University of Medical Sciences, Shahroud, 3614773955, Iran

    Majid Salehi

  3. Sexual Health and Fertility Research Center, Shahroud University of Medical Sciences, Shahroud, 3614773955, Iran

    Majid Salehi, Keyvan Shahporzadeh, Hodays Yeganehfard, Heliya Ziaei, Mohammad Moein Azizi & Amirreza Tahersoltani

  4. Department of Mechanical Engineering, Science and Research Branch, Islamic Azad University, Tehran, 1477893855, Iran

    Arian Ehterami

  5. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, 1417755354, Iran

    Saeed Farzamfar, Jafar Ai & Akbar Ahmadi

  6. Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, 1416753955, Iran

    Jafar Ai

  7. Department of Tissue Engineering, School of Medicine, Fasa University of Medical Sciences, Fasa, 7461686688, Iran

    Arash Goodarzi

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  1. Majid Salehi
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Correspondence to Jafar Ai or Akbar Ahmadi.

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Salehi, M., Shahporzadeh, K., Ehterami, A. et al. Electrospun Poly(ε-caprolactone)/Gelatin Nanofibrous Mat Containing Selenium as a Potential Wound Dressing Material: In Vitro and In Vivo Study. Fibers Polym 21, 1713–1721 (2020). https://doi.org/10.1007/s12221-020-9825-8

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  • DOI: https://doi.org/10.1007/s12221-020-9825-8

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