On the Potential Role of the Neural Crest Cells in Integrating Pigmentation Into Behavioral and Physiological Syndromes
Luis M. San-Jose
Alexandre Roulin- 1Laboratoire Évolution and Diversité Biologique, UMR 5174, CNRS, Université Toulouse III Paul Sabatier, Toulouse, France
- 2Department of Ecology and Evolution, University of Lausanne, Lausanne, Switzerland
Melanin pigments color the integument of vertebrates with shades of rufous, gray, and black. In numerous wild species, melanin-based coloration associates to different behavioral, physiological, and morphological traits, yet the proximate basis of such associations remains largely unknown. The neural crest/domestication syndrome hypothesis (Wilkins et al., 2014) proposes that correlated changes in pigmentary, behavioral, physiological, and morphological traits of domestic species result from deficiencies affecting the number or development of neural crest cells in the embryo. Here, we review to what extent the neural crest cells might also explain the associations observed between melanin-based coloration and distinct traits in wild vertebrate populations. Genes involved in the development of the neural crest explain color differences in some vertebrate species, particularly, in cichlid fishes. Cells that originate from the embryo’s neural crest cells play functions that have been previously associated with melanin-based coloration in wild vertebrates and we propose the potential mechanisms through which the association of melanin-based coloration with other traits can be the consequence of having a common origin at the neural crest cells. We encourage considering the influence of the neural crest as a new avenue of research, integrating developmental biology and evolutionary ecology to better understand why and how melanin-based coloration of vertebrates become associated to multiple phenotypic aspects.
Introduction
Most vertebrates color their integuments with melanin pigments (Roy et al., 2020). When deposited in the skin, feathers, scales or hairs, melanins produce different shades of black, gray, and rufous colors (e.g., Stoddard and Prum, 2011). Coloration based on melanin pigments (hereafter referred to as melanin-based coloration, MbC) can play different biological functions such as protecting animals from UV radiation (Brenner and Hearing, 2008; Singaravelan et al., 2008), promoting thermal adaptation by regulating heat gain (Clusella-Trullas et al., 2008), and mediating social and mating encounters in the case of melanin-based ornamental signals (Roulin, 2016).
Moreover, studies in wild vertebrate populations have repeatedly shown that the expression of MbC is associated with multiple aspects of an individual’s phenotype including physiology (metabolism, stress response and stress hormone levels), immunology (inflammatory response and parasite load), morphology (body size and mass), behavior (aggressiveness, boldness, and exploratory behavior) and reproductive traits (sex hormone levels and fecundity) (reviewed in San-Jose and Roulin, 2018). Often, these associations have the same sign in different species. For instance, individuals with a darker or more extended MbC (i.e., entailing a higher deposition of melanin pigments, generally eumelanin) have been often found to be more aggressive and/or to have a higher social rank in different vertebrate taxa, including fishes (Schweitzer et al., 2015), amphibians (Reiter et al., 2014), testudines (Mafli et al., 2011), squamates (Plasman et al., 2015), birds (Santos et al., 2011), and mammals (Loehr et al., 2008).
The recurrent association of MbC with the same traits across vertebrates suggests the existence of shared developmental, genetic, and/or selective mechanisms that link the expression of MbC with other phenotypic aspects (Ducrest et al., 2008; Roulin and Ducrest, 2011; San-Jose and Roulin, 2018). Vertebrate MbC thus constitutes a good model system to address questions of general relevance for evolutionary biologists, particularly those regarding the evolution of the phenotype that acknowledge its multidimensional nature. The study of the proximate and ultimate causes underlying the association of MbC to other, disparate traits can offer insights into the molecular basis of trait correlations (Saltz et al., 2017), into how complex organisms evolve and adapt (Orr, 2000; Wagner et al., 2007; Melo et al., 2016) and how developmental and genetic constraints and trade-offs influence evolutionary trajectories, adaptation, and species differentiation (Smith et al., 1985; West-Eberhard, 2005; Mauro and Ghalambor, 2020).
With this review, our aim is to draw attention toward a new, potentially explanatory mechanism linking MbC with other phenotypic aspects in wild vertebrate populations. Research on domestic mammals has also encountered the recurrent association of MbC with different morphological and behavioral traits, a phenomenon already highlighted by Darwin and that was named the “domestication syndrome” (Wilkins et al., 2014, see also Sánchez-Villagra et al., 2015). Wilkins et al. (2014; see also Wilkins, 2019) proposed that many of the phenotypes often displayed by domestic mammals: depigmentation, floppy ears, smaller brains, reduced tooth size, higher fecundity, can be explained by deficiencies affecting the initial numbers and/or the capacity to migrate and differentiate of the cells in the neural crest, NC. Cells in the NC are the precursors of pigment cells, including melanocytes (sensu Schartl et al., 2016), as well as of different types of endocrine cells, mesenchymal cells, and neuron and glial cells (Douarin et al., 2008; Monsoro-Burq, 2015; Simões-Costa and Bronner, 2015; Rothstein et al., 2018; Etchevers et al., 2019). This shared origin increases the likelihood that genetic and environmental factors affecting the NC cells’ normal development result in parallel changes in the different cell types deriving from the NC and thus, on correlated changes in different phenotypic aspects (Wilkins et al., 2014). We explore here if the ideas of Wilkins et al. (2014) can be exported outside domestic mammals and used in future studies to explore the yet unknown causes linking MbC and multiple phenotypic aspects in wild vertebrate populations.
Neural Crest Cells and Color Variation in Wild Animals
The neural crest, NC, is a transitory structure exclusive to the vertebrates’ embryo (Donoghue et al., 2008; Shimeld and Holland, 2000). It is a cord of cells that originates from the neural plate borders and arises approximately when the neural plates join to form the embryo’s neural tube (Simões-Costa and Bronner, 2015; Etchevers et al., 2019; Figures 1A,B). Cells in the NC initially lie between the dorsal ectoderm and the neural tube but, as the embryo develops, NC cells migrate to different locations, settle, and differentiate, giving rise to a remarkably wide array of cell types (Rothstein et al., 2018; Etchevers et al., 2019; Figure 1C). The specific processes underlying NC cell migration and differentiation into melanocytes and other cells types can be found in several recent reviews (Thomas and Erickson, 2008; Kelsh et al., 2009; Mills and Patterson, 2009; Etchevers et al., 2019) as well as the latest advances in deciphering the intrincated genetic network regulating each step of the NC development and differentiation (Simões-Costa and Bronner, 2015; Martik and Bronner, 2017; Hockman et al., 2019).
Figure 1. The neural crest is a transitory structure of the vertebrate embryo that initially locates on the most dorsal part of the neural tube. During development, cranial and trunk neural crest cells migrate to different parts of the embryo depending on where they originated (A). The neural crest is formed from the borders of the neural plate. The neural plate folds forming the neural tube, and neural crest cells will delaminate from the neural plate and migrate from the space between the neural tube and the ectoderm to reach different locations in the body (B). During migration and at their arrival sites, neural crest cells commit and differentiate into a wide range of cell types (C).
A first question is to understand the type of color variation that any factors affecting the NC cells might end up having in the expression of MbC and to what extent such NC-related variation mirrors the variation in MbC that we often observe and study in wild vertebrate populations. As shown by studies in the zebrafish, Danio rerio, variation in NC cells development can be expected to affect whether or not melanocytes are present in a given location of the body, and if present, in what numbers and whether they display a normal morphology (Kelsh et al., 1996). Thus, variation in NC cells development might potentially account for discrete or continuous variation in color patterns among individuals, differences in color intensity, or differences in the size of a color patch. These are all sources of variation in MbC that are often studied in wild populations (Luiselli et al., 1995; Horth, 2003; Bortolotti et al., 2006; Quesada and Senar, 2007; Gratten et al., 2008; Loehr et al., 2008; Kittilsen et al., 2009; Lepetz et al., 2009; Laucht et al., 2010; Roulin et al., 2010; Rosenblum et al., 2010; Mateos-Gonzalez and Senar, 2012; Chen et al., 2013; Kim et al., 2013; Saino et al., 2013; Reiter et al., 2014; Johnson and Fuller, 2015; McGlothlin et al., 2016; Tate et al., 2016; Evans and Gustafsson, 2017; Kappers et al., 2018; Romero-Diaz et al., 2019; San-Jose et al., 2019; Santostefano et al., 2019).
While variation at the level of NC development has the capacity to result in diverse and substantial changes in vertebrate coloration, evidence showing that NC cells underlie intraspecific color variation in wild species is still scarce. Variation in NC cells development can have a genetic origin (Kelsh et al., 1996; Rothstein et al., 2018; Hovland et al., 2019), although environmental factors such as temperature, maternal nutritional status and oxidative stress can also affect NC development (Finnell et al., 2004; Običan et al., 2010; Xu et al., 2013; Dreier et al., 2014). To date, genetic studies in cichlid fish species of the lake Malawi offer the best evidence of the involvement of NC cells in producing color variation in wild species, particularly through cis-regulatory mutations in Pax genes. The expression of Pax 3 and Pax 7 genes is required for the formation of the neural crest and, together with other genes in the Pax family, they regulate NC cells proliferation, migration, and specification into different cell types, including melanocytes (Minchin and Hughes, 2008; Monsoro-Burq, 2015; Hovland et al., 2019). In cichlid fishes, differential expression of the Pax3a gene would be implicated in continuous variation in the levels of melanophores and xanthophores (Albertson et al., 2014), whereas the upregulation of the gene Pax7a would underlie female blotch polymorphism in different cichlid species (Roberts et al., 2009), with different Pax7a alleles leading to changes in the number, size, and spread of melanophores (Roberts et al., 2017). Other genes such as csf1r, edn3b, and ednrB1a, which are actively involved in the migration of NC cells (Minchin and Hughes, 2008; Kelsh et al., 2009) have been suggested to underlie the formation of the characteristic egg spots or egg dummies present in the anal fins of several cichlid species (Salzburger et al., 2007; Diepeveen and Salzburger, 2011; Santos et al., 2014). The genes Ednrb1 and Tfap2a were found to be upregulated in the dark morph vs. the gold morph of the Midas cichlid, Amphilophus citrinellus (Henning et al., 2010).
Other key genes in the development of the NC cells, particularly involved in NC cells commitment and differentiation into melanocytes, have been suggested to underlie color differences between populations or species. In mouse, chicken and zebrafish, the expression of the melanocyte inducing transcription factor, MITF (mitfa in the zebrafish), is required for the production of mature melanocytes from the NC cells (Opdecamp et al., 1997; Goding, 2000; Johnson et al., 2011). In wild populations, MITF has been identified as a candidate gene underlying the characteristic color pattern of African wild dogs (Lycaon pictus) (Campana et al., 2016), and plumage color variation among populations of pied flycatchers (Ficedula hypoleuca) (Lehtonen et al., 2012). MITF might be also involved in plumage color differences between carrion and hooded crows (Corvus corone corone and C. c. cornix) (Poelstra et al., 2015). Reduced expression of the Kit ligand gene, which is involved in the survival and migration of melanoblasts (Kelsh et al., 2009), has been linked to reduced melanization of ventral body parts in some populations of threespine stickleback fish (Gasterosteus aculeatus).
Non-Pigmentary Neural Crest Derived Tissues: Functions and Links With Melanin-Based Coloration
In addition to pigment cells, the NC derivatives include different types of endocrine cells, mesenchymal cells, and neuron and glial cells (Douarin et al., 2008; Monsoro-Burq, 2015; Simões-Costa and Bronner, 2015; Rothstein et al., 2018; Etchevers et al., 2019). Here, we briefly review the main functions of these other cell types, highlighting if such functions also relate to phenotypic aspects observed in association with MbC in wild vertebrate populations.
Endocrine cells deriving from NC cells include adrenal medullary cells, carotid body glomus cells, and calcitonin-secreting cells of the ultimobranchial body (although the NC-cell origin of this later cell type has been questioned recently; Nilsson and Williams, 2016). Adrenal medullary cells, also known as chromaffin cells or pheochromocytes, are responsible for the synthesis and secretion of catecholamines (epinephrine, nor-epinephrine, and dopamine) as part of the sympatho-adrenal system (Kvetnansky et al., 2009). Catecholamines are released in response to stressors, which triggers different physiological and neuronal changes oriented to surmount the stressful conditions (e.g., increased heart rate, blood pressure, cellular metabolism, glucose levels in blood, among others). The association between MbC and stress response has been studied in different vertebrate species where darker individuals have been often found to be more resistant to stress (reviewed in San-Jose and Roulin, 2018). The association between MbC and stress is mainly considered within the context of the hypothalamus-pituitary-adrenocortical system and thus in relation to the stress hormones released by the cortex and not by the medulla of the adrenal glands (Husak and Moore, 2008; Roulin, 2016). However, the potential implication of catecholamines and the sympatho-adrenal system in explaining why MbC associates to stress response deserves further attention, considering also the potential interactions with the hypothalamus-pituitary-adrenocortical system (e.g., the adrenal medulla may regulate hormone secretion by the adrenal cortex and vice versa: Gallo-Payet et al., 1987; Kvetnansky et al., 2009). The fact that catecholamines can induce color changes in vertebrates (Bagnara and Matsumoto, 2007; Zhang et al., 2020) increases the interest of investigating their role in linking coloration and stress response.
Epinephrine and nor-epinephrine levels are also related with behavioral traits such as aggressiveness, boldness, and social dominance (Koolhaas et al., 1999, 2010; Chichinadze, 2004; Vaz-Serrano et al., 2011), which are often associated with MbC (Ducrest et al., 2008; Santos et al., 2011; San-Jose and Roulin, 2018). Dopamine plays also an important role in regulating aggressive behaviors (Pavlov et al., 2012). However, dopamine does not cross the blood-brain barrier and thus the dopamine secreted by adrenal medulla is not expected to influence aggressiveness contrary to the dopamine secreted in brain tissues (Waltes et al., 2016). Peripheral dopamine (i.e., the dopamine secreted by the adrenal medulla among other tissues) is suspected to regulate metabolism, food intake, and body weight (Rubí and Maechler, 2010), which are also aspects that has been found to differ between individuals with distinct MbC.
Calcitonin-secreting cells of the ultimobranchial body produces calcitonin, the parathyroid hormone, which has a central role in regulating calcium and phosphorus levels (Naot et al., 2018). The link between MbC and calcium levels have received some attention in birds, where increased levels of calcium in the diet enhance MbC expression (McGraw, 2003, 2007, although see Stewart and Westneat, 2010) and where melanin-pigmented feathers have been observed to accumulate more calcium (Niecke et al., 1999, 2003). One study in barn owls (Tyto alba) also showed that calcium content in bones is higher in individuals presenting more eumelanic spots in their plumage, suggesting that a link between the expression of MbC and calcium physiology may exist (Roulin et al., 2006). A closer look on the association between MbC, calcitonin, and calcitonin-secreting cells may offer new insights into the links between MbC and calcium.
Carotid body glomus cells sense changes in oxygen tension and trigger the activation of the brainstem respiratory center to induce hyperventilation in response to hypoxemia (Lopez-Barneo et al., 2008). In some species, rapid change in skin coloration in response to temperature changes seems to be dependent on oxygen levels (de Velasco and Tattersall, 2008, although see also Rahn, 1956). However, we are not aware of studies directly showing that differences in MbC between individuals relate to differences in dealing with hypoxemia or hypoxia. Yet, we expect MbC and the response to low oxygen levels to be co-selected in high altitude environments (Leaché et al., 2010; Reguera et al., 2014), where darker MbC are expected to be favored at low temperatures (Delhey, 2017).
NC gives rise to the neurons and the glial cells of the ganglia of the peripheral nervous system (PNS) (Jessen, 2004; Bhatheja and Field, 2006). The autonomous PNS promotes the release of catecholamines by the adrenal medulla in response to stress (the sympatho-adrenal system), whose potential link to MbC has been discussed lines above. The autonomous PNS participate in the stress response also through the sympatho-neural system (Del Giudice et al., 2011). The sympatho-neural system is involved in regulating the immune response (Jänig, 2014), also a phenotypic aspect that has been often associated with differences in MbC (Côte et al., 2018). Another aspect that has been associated often with MbC is sexual behavior, sex steroid concentration, and fecundity (San-Jose and Roulin, 2018). The PNS regulates the production of sex hormones via sympathetic innervation of the gonads (Lara et al., 2002; Daneri et al., 2013; Bronzi et al., 2015) while the parasympathetic system has been related to sexual arousal (Giuliano et al., 2002).
Finally, NC crest cells give rise to the mesenchymal cells that further differentiate into many of the numerous distinct cells that form the organs and tissues of the head of vertebrates. Thus, NC cells differentiate into osteocytes and chondrocytes forming the facial skeleton, and the inner ear, odontoblasts producing the dentine of the teeth, and muscle and cartilage cells of the face, among others (Kaucka et al., 2016; Etchevers et al., 2019). To the best of our knowledge, head morphology has been found in association to MbC in at least one study. San-Jose et al. (2017) found that common lizards, Zootoca vivipara, with a more melanized ventral coloration had a larger head and a stronger bite force even when controlling for body size differences.
Potential Mechanisms of Covariation
In the previous sections, we have reviewed that (i) genetic factors linked to NC development explain color variation in some wild vertebrate species and that (ii) non-pigmentary NC derived tissues participate in functions previously found to be associated with MbC in wild species. We argue that these two general observations justify considering the shared developmental origin of melanocytes and other NC derivatives as a potential linking mechanism underlying the associations of MbC with other phenotypic aspects in wild vertebrates; i.e., an hypothesis to be addressed in future studies.
Genetic or environmental factors affecting the proliferation, migration, and/or initial stages of differentiation of the NC cells may impact both coloration and the functions of other NC-derived tissues in post-embryonic stages. Such mechanism of covariation was pushed forward by Wilkins et al. (2014) as an explanation for the domestication syndrome. A direct example of such a mechanism can be found on recent findings showing how mutations at the gene ADAR1 pleiotropically disrupt the development of both melanocytes and Schwann cells (the major type of glial cell of the PNS: Gacem et al., 2020). The potential for pleiotropic effects will depend on which steps of the NC development are affected by genetic or environmental factors. For instance, genetic changes as those discussed in relation to Pax3/7 genes in cichlid fishes have the capacity of affecting multiple phenotypic traits besides MbC. The reason is that Pax3/7 genes are key for the development of the NC before NC cells start to commit and differentiate into different cell types (Martik and Bronner, 2017). Thus, changes in the functioning of Pax3/7 genes may have effects that can be inherited by different cell types. Contrarily, other genes such as MITF that may also associate to color differences in the wild have a lower potential for pleiotropic action. MITF regulates final stages of NC cells development: the differentiation of a population of NC cells into melanocytes (Martik and Bronner, 2017).
There are other mechanisms through which MbC and other phenotypic traits can become linked due to the functioning of other NC-derived tissues. A second mechanism of covariation might rely on the fact that multipotent NC stem cells persist in adult peripheral nerves. Such stem cells are able to leave the PNS nerves and differentiate into melanocytes (Singh et al., 2016; Dupin et al., 2018; Mehrotra et al., 2020). Thus, factors, either genetic or environmental, affecting this population of multipotent NC stem cells might have cascading effects on different tissues, linking the expression of MbC with other phenotypic traits. A third mechanism of covariation might be based on a direct regulation of pigmentation by the functioning of some NC-derived tissues. One example of such mechanism comes from the recent discovery of how acute stress triggers hair whitening in mammals (Zhang et al., 2020). In response to acute stress, the PNS releases norepinephrine through the sympathetic nerves that innervate melanocyte stem-cells in the hair bulb. This causes melanocyte stem-cells to rapidly proliferate and differentiate into mature melanocytes, which eventually extenuates the niche of melanocyte stem-cells and causes hair whitening. In reptiles, fishes and amphibians, catecholamines released by the adrenal medulla had been known for long to play an important role in regulating melanophore contraction and MbC (Bagnara and Matsumoto, 2007). As discussed above, this may constitute a direct link between pigmentation, stress response, and perhaps, behavior.
Final Notes
Inspired by the ideas of Wilkins et al. (2014), we highlight here the potential role of the NC cells to drive associations between MbC and other phenotypic aspects in wild vertebrates. Such associations may result from other proposed mechanisms (reviewed in San-Jose and Roulin, 2018), among which, the pleiotropic action of the genes in the melanocortin system has received substantial attention (Ducrest et al., 2008). The genes in the melanocortin system regulate melanin synthesis as well as different aspects of behavior, morphology and physiology. As we review above, some of this aspects have also a developmental origin in the NC: stress response, metabolism, aggressiveness, sexual behavior, sex hormone levels, metabolism, body weight, and immune response. We think that different mechanisms such as the NC and the melanocortin system do not necessarily constitute competing hypotheses as to how MbC becomes associated with other phenotypic traits. Contrarily, they may even act in a complementary way given that they are expected to associate to the same phenotypic aspects through distinct pathways (e.g., the NC cells associate to the stress response through the sympatho-adrenal and sympatho-neural systems and the melanocortin system through the hypothalamus-pituitary-adrenocortical system). Like the NC, the melanocortin system is specific of the vertebrate lineage, having its origin in early chordates (Cortés et al., 2014). We find remarkable as well as intriguing that both, the NC and the melanocortin systems constitute shared developmental and genetic mechanisms underlying the expression of similar phenotypic aspects of vertebrates. This raises the question of whether the co-expression of such traits: MbC, metabolism, stress response, sexual behavior might have had any selective advantage in the conditions in which vertebrate ancestors evolved. Or, contrarily, whether the fact that MbC and other phenotypic traits shared aspects of their development and regulation may be simply due to historical contingencies.
In current vertebrate populations, mechanisms such as the NC and the melanocortin system offer high potentiality for pleiotropic regulation of MbC and several other phenotypic traits. If genetic variation for such pleiotropic regulation exists selection can shape associations between MbC and phenotypic traits (Lande and Arnold, 1983). Acting in a correlational manner, selection on MbC and other traits can promote complex adaptations (Wagner and Altenberg, 1996), for instance, in ecological scenarios such as in low temperature habitats where having a darker pigmentation, a larger body size, a higher metabolism, a higher stress resistance might all be advantageous (San-Jose and Roulin, 2018). Plausible proximate mechanisms of covariation between MbC and other phenotypic traits also increase the likelihood for indirect selection driving trait associations as well as for the existence of developmental and genetic constraints to adaptation (Orr, 2000). By being shared across vertebrates, mechanisms of covariation such as the NC cells and the melanocortin system may help us understand why and how similar association between MbC and other phenotypic traits can be recurrently found within (e.g., Santos et al., 2011) and across distinct vertebrate taxa (Eliason and Clarke, 2018).
Research on the potential role of the NC cells in linking different phenotypic aspects will thus offer insights into both the proximate and ultimate causes of associations between MbC and distinct phenotypic traits. Taxa such cichlid fish seem good model species to test for correlated changes between MbC and other traits with developmental roots in the NC and to investigate how selection might be jointly acting on MbC and associated traits. Cichlid fish are also a good system to investigate how NC cells and the melanocortin system interact and affect different traits (Dijkstra et al., 2017). The zebra fish, Danio rerio, is also a promising model system in controlled laboratory conditions, taking advantage of the different existing color mutants for NC-related genes (Singh and Nüsslein-Volhard, 2015). We expect that research on how the NC origin of MbC might result in associations of coloration with ecologically relevant traits will bring together developmental biology and evolutionary ecology to better understand the evolution of animal coloration.
Author Contributions
LS-J and AR conducted the review and synthesis of the literature and wrote the manuscript. Both authors contributed to the article and approved the submitted version.
Funding
We acknowledge the Swiss National Science Foundation for funding (ref: 173178 to AR).
Conflict of Interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Acknowledgments
We are grateful to Jessica Delhaye, Adam S. Wilkins, and two reviewers for their constructive comments on earlier versions of our manuscript.
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Keywords: animal signals, aggressiveness, eco-evo-devo, behavior, melanism, pigmentation, phenotypic integration, trait associations
Citation: San-Jose LM and Roulin A (2020) On the Potential Role of the Neural Crest Cells in Integrating Pigmentation Into Behavioral and Physiological Syndromes. Front. Ecol. Evol. 8:278. doi: 10.3389/fevo.2020.00278
Received: 29 February 2020; Accepted: 05 August 2020;
Published: 02 September 2020.
Edited by:
Marie Manceau, Collège de France, FranceReviewed by:
Pedro Martinez, University of Barcelona, SpainPatricia Johnston Moore, University of Georgia, United States
Copyright © 2020 San-Jose and Roulin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Luis M. San-Jose, luismsanjose@gmail.com