Eicosapentaenoic acid ameliorates pulmonary hypertension via inhibition of tyrosine kinase Fyn
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Graphical abstract
Abbreviations
5-HT
5-hydroxytryptamine
α-SMA
α-smooth muscle actin
EndoMT
Endothelial-mesenchymal transition
EPA
Eicosapentaenoic acid
HR
Heart rate
HPAECs
Human pulmonary artery endothelial cells
HPASMCs
Human pulmonary artery smooth muscle cells
IPAH
Idiopathic pulmonary arterial hypertension
IL-6
Interleukin-6
KM-FYN
Dominant negative Fyn
MCT
Monocrotaline
PAs
Pulmonary arteries
PAAT
Pulmonary artery acceleration time
PAH
Pulmonary arterial hypertension
p-STAT3
phosphorylated STAT3
RvE1
Resolvin E1
RVID
Right ventricular internal diameter
RVWT
Right ventricular wall thickness
STAT3
Signal transducer and activator of transcription 3
TGF-β2
Transforming growth factor-β2
VE-cadherin
Vascular endothelial cadherin
FY-FYN
Constitutively active Fyn
Keywords
Eicosapentaenoic acid
Pulmonary arterial hypertension
Src family tyrosine kinases
Human pulmonary artery endothelial cells
Endothelial-to-mesenchymal transition
Human pulmonary artery smooth muscle cells
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Contributed equally.
© 2020 The Authors. Published by Elsevier Ltd.