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Validated Electrochemical Method for Simultaneous Resolution of Tyrosine, Uric Acid, and Ascorbic Acid at Polymer Modified Nano-Composite Paste Electrode

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Abstract—

In this work, an electrochemical sensor based on a poly threonine modified graphite-carbon nanotube paste electrode was developed for the investigation of tyrosine. The modification of the electrode was characterized by field emission scanning electron microscopy, cyclic voltammetry, and differential pulse voltammetry. The modified electrode shows many advantages such as simple preparation, good sensitivity, short response time, good stability and reproducibility. The developed electrode was highly selective because of the determination of tyrosine in the presence of the ascorbic acid and the uric acid. Under optimal conditions; the cyclic voltammetry provides a linear response with the concentration range from 2 × 10–6 to 2.5 × 10–5 M and 3 × 10–5 to 1.2 × 10–4 M with the limit of detection and limit of quantification values of 2.9 × 10–7 and 9.6 × 10–7 M. The developed sensor was employed for tyrosine detection in pharmaceutical sample, recoveries obtained were in a range of 99.0 to 102.80%.

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Funding

The authors gratefully acknowledge the financial support from the Vision Group on Science and Technology, Bangalore, India under the Research Project KSTePS/VGST-KFIST (L1) 2016-2017/GRD-559/2017-2018/126/333, 21/11/2017.

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Authors and Affiliations

  1. Department of Chemistry, FMKMC College, Madikeri, Mangalore University Constituent College, 571201, Karnataka, India

    Chenthattil Raril & Jamballi G. Manjunatha

  2. Department of Chemistry, Sri Mahadeshwara Goverment First Grade College, Kollegal, 571440, Karnataka, Chamarajanagar, India

    Doddarasinakere K. Ravishankar

  3. School of Pharmacy, Management and Science University, 40100, Malaysia

    Santosh Fattepur

  4. Department of Chemistry, JSS College for women Chamarajanagar, 571313, Karnataka, India

    Gurumallappa Siddaraju

  5. UGC – Human Resource Development Centre, University of Mysore, Manasagangotri, 570006, Mysore, Karnataka, India

    Lingappa Nanjundaswamy

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  1. Chenthattil Raril
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  2. Jamballi G. Manjunatha
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Correspondence to Jamballi G. Manjunatha.

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Chenthattil Raril, Manjunatha, J.G., Ravishankar, D.K. et al. Validated Electrochemical Method for Simultaneous Resolution of Tyrosine, Uric Acid, and Ascorbic Acid at Polymer Modified Nano-Composite Paste Electrode. Surf. Engin. Appl.Electrochem. 56, 415–426 (2020). https://doi.org/10.3103/S1068375520040134

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