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The Relationship between Hierarchical Chiral Structures of Proteins and their Functions

  • MOLECULAR BIOPHYSICS
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Abstract

The specific characteristics of the distribution of secondary structures and coiled-coil superhelix structures were investigated for the first time, while taking the sign of chirality into account, in polypeptide chains of proteins belonging to eight functional classes: viral proteins, chaperones, oxidoreductases, hydrolases, structural proteins, proteins involved in exocytosis and endocytosis, and electron-transport proteins. The patterns of protein structure that are common for all studied classes and those typical for each class are described.

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REFERENCES

  1. P. Y. Chou and G. D. Fasman, Adv. Enzymol. Relat. Areas Mol. Biol. 47, 45 (1978).

    Google Scholar 

  2. A. A. Adzhubei, F. Eisenmenger, V. G. Tumanyan, et al., J. Biomol. Struct. Dyn. 5 (3), 689 (1987).

    Article  Google Scholar 

  3. A. A. Zamyatnin, Aktual. Vopr. Biol. Fiz. Khim. 3 (1), 225 (2018).

    Google Scholar 

  4. V. A. Tverdislov, arXiv 1211, 4272 (2012).

  5. V. A. Tverdislov, Biophysics (Moscow) 58 (1), 128 (2013).

    Article  Google Scholar 

  6. V. A. Tverdislov, E. V. Malyshko, S. A. Il’chenko, et al., Biophysics (Moscow) 62 (3), 331 (2017).

    Article  Google Scholar 

  7. V. A. Tverdislov, E. V. Malyshko, Usp. Fiz. Nauk 189, 375 (2019).

    Article  Google Scholar 

  8. A. V. Finkelstein and O. B. Ptitsyn, Protein Physics: A Course of Lectures with Color and Stereoscopic Illustrations and Problems with Solutions, 3rd extended ed. (KDU, Moscow, 2012) [in Russian].

  9. V. A. Tverdislov, A. E. Sidorova, and L. V. Yakovenko, Biophysics (Moscow) 57 (1), 120 (2012).

    Article  Google Scholar 

  10. RCSB PDB: http://www.rcsb.org.

  11. A. S. Ivanov, Biomed. Khim. 57 (1), 31 (2011).

    Article  Google Scholar 

  12. CC+ database: http://coiledcoils.chm.bris.ac.uk/ ccplus.

  13. Yu. I. Khurgin, D. S. Chernavskii, and S. E. Shnoll, Mol. Biol. (Moscow) 1, 419 (1967).

    Google Scholar 

  14. L. A. Blumenfeld, Solvable and Unsolvable Problems of Biological Physics (Editorial URSS, Moscow, 2002) [in Russian].

    Google Scholar 

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Funding

This work was supported in part by the Russian Science Foundation, grant no. 19-74-00082.

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Authors and Affiliations

  1. Department of Physics, Moscow State University, 119991, Moscow, Russia

    E. V. Malyshko, O. E. Bagrova & V. A. Tverdislov

Authors
  1. E. V. Malyshko
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  2. O. E. Bagrova
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  3. V. A. Tverdislov
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Corresponding author

Correspondence to E. V. Malyshko.

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Conflict of interests. The authors declare that they have no conflict of interest.

Statement on the welfare of animals. This article does not contain any studies involving animals or human participants performed by any of the authors.

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Translated by D. Timchenko

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Malyshko, E.V., Bagrova, O.E. & Tverdislov, V.A. The Relationship between Hierarchical Chiral Structures of Proteins and their Functions. BIOPHYSICS 65, 368–373 (2020). https://doi.org/10.1134/S0006350920030148

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  • DOI: https://doi.org/10.1134/S0006350920030148

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