Abstract
In this paper, we discuss experimental data obtained during study of the effect of a low-frequency alternating magnetic field on the conformational transitions of human serum albumin in the presence of silver nanoparticles using fluorescence spectroscopy at different pH values. A sharp increase in the albumin fluorescence intensity was detected in the presence of silver nanoparticles; this effect changed when exposed to a low-frequency alternating magnetic field. The resulting calculation formula for cross section of light scattering by a spherical nanoparticle of a certain radius allows calculation of the sizes of nano-microstructures based on nanoparticles and natural biopolymers of the “core–shell” type, whose physicochemical properties can be controlled by a magnetic field. The proposed model for the formation of protein–nanoparticle associates in the solution by the dipole–dipole mechanism is in good agreement with the experimental data.
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The authors declare that they have no conflict of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.
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Translated by G. Levit
Abbreviations: HSA, human serum albumin; MF, magnetic field.
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Tekutskaya, E.E., Baryshev, M.G., Tumaev, E.N. et al. The Effect of an Alternating Magnetic Field and Silver Nanoparticles on the Spectral Characteristics of an Aqueous Solution of Human Serum Albumin. BIOPHYSICS 65, 404–409 (2020). https://doi.org/10.1134/S0006350920030203
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DOI: https://doi.org/10.1134/S0006350920030203