Neuron
Volume 108, Issue 3, 11 November 2020, Pages 401-412
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Perspective
How Can Hearing Loss Cause Dementia?

https://doi.org/10.1016/j.neuron.2020.08.003Get rights and content
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Summary

Epidemiological studies identify midlife hearing loss as an independent risk factor for dementia, estimated to account for 9% of cases. We evaluate candidate brain bases for this relationship. These bases include a common pathology affecting the ascending auditory pathway and multimodal cortex, depletion of cognitive reserve due to an impoverished listening environment, and the occupation of cognitive resources when listening in difficult conditions. We also put forward an alternate mechanism, drawing on new insights into the role of the medial temporal lobe in auditory cognition. In particular, we consider how aberrant activity in the service of auditory pattern analysis, working memory, and object processing may interact with dementia pathology in people with hearing loss. We highlight how the effect of hearing interventions on dementia depends on the specific mechanism and suggest avenues for work at the molecular, neuronal, and systems levels to pin this down.

Keywords

dementia
hearing loss
medial temporal lobe
Alzheimer disease
auditory cognition

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6

These authors contributed equally

7

Senior author

8

Lead Contact