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Electro-Stimulated Release of Poorly Water-Soluble Drug from Poly(Lactic Acid)/Carboxymethyl Cellulose/ZnO Nanocomposite Film

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Abstract

Purpose

Among various types of external stimuli-responsive DDS, electric-responsive DDS are more promising carriers as they exploit less complex, easily miniaturized electric signal generators and the possibility of fine-tuning the electric signals. This study investigates the use of intrinsically biocompatible biopolymers in electro-simulative drug delivery to enhance the release of poorly-soluble/non-ionic drug.

Methods

CMC/PLA/ZnO/CUR nanocomposite films were prepared by the dispersion of CMC and ZnO NPs in solubilized PLA/curcumin medium, followed by solvent casting step. Curcumin is poorly water-soluble and used as the model drug in this study. The films with different contents of CMC, PLA and ZnO NPs were characterized using FTIR, impedance spectroscopy, tensile testing and FESEM imaging. The in vitro drug release of the films was carried out in deionized water under DC electric field of 4.5 V.

Results

The ionic conductivity of the films increased with increasing the CMC concentration of the film. The addition of a small amount of ZnO NPs (2%) successfully restored the tensile properties of the film. In response to the application of the electric field, the composite films released drug with a near-linear profile. There was no noticeable amount of passive diffusion of the drug from the film with the absence of the electric field.

Conclusion

The outcome of this study enabled the design of an electric-responsive nanocomposite platform for the delivery of poorly water-soluble/non-ionic drugs.

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Abbreviations

ANOVA:

Analysis of variance

ATR:

Attenuated total reflection

CMC:

Carboxymethyl cellulose

CPE:

Constant phase element

CTC:

Charge transfer complexes

CUR:

Curcumin

DC:

Direct current

DDS:

Drug delivery systems

DEX:

Dexamethasone

FESEM:

Field emission scanning electron microscopy

FTIR:

Fourier-transform infrared spectroscopy

GO:

Graphene oxide

NP:

Nanoparticle

PBS:

Phosphate-buffered saline

PLA:

Poly(lactic acid)

PPy:

Polypyrrole

PVA:

Polyvinyl alcohol

SGF:

Simulated gastric fluid

UV:

Ultraviolet

Zi:

Frequency dependence impedance properties- reactive part

Zr:

Frequency dependence impedance properties-real part

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Authors and Affiliations

  1. Centre of Advanced Materials (CAM), Faculty of Engineering, University of Malaya, 50603, Kuala Lumpur, Malaysia

    Thennakoon M. Sampath U. Gunathilake & Yern Chee Ching

  2. Department of Chemical Engineering, Faculty of Engineering, University of Malaya, 50603, Kuala Lumpur, Malaysia

    Thennakoon M. Sampath U. Gunathilake & Yern Chee Ching

  3. Department of Chemistry, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia

    Cheng Hock Chuah

  4. Institute of Research and Development, Duy Tan University, Danang, 550000, Vietnam

    Nguyen Dai Hai

  5. Institute of Applied Materials Science, Vietnam Academy Science and Technology, 01 TL29 District 12, Ho Chi Minh City, 700000, Vietnam

    Nguyen Dai Hai

  6. Department of Mechanical Engineering, Southern Taiwan University of Science and Technology, 710 Tainan City, Taiwan, Republic of China

    Liou Nai-Shang

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  1. Thennakoon M. Sampath U. Gunathilake
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Highlights

Poly(lactic acid)/carboxymethyl cellulose/ZnO/curcumin nanocomposite film was prepared using solvent casting method.

The emulsification and electrophoretic properties of carboxymethyl cellulose have been utilized for the electro-stimulated drug delivery process.

The study demonstrates the approach to trigger the release of poorly water-soluble and non-ionic drugs under electric stimulation.

The film does not show noticeable natural drug release providing that the total control of drug release under electrical stimulation.

The biopolymers provide an alternative for the use of nondegradable conductive polymers in electro-simulative drug delivery systems.

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Gunathilake, T.M.S.U., Ching, Y.C., Chuah, C.H. et al. Electro-Stimulated Release of Poorly Water-Soluble Drug from Poly(Lactic Acid)/Carboxymethyl Cellulose/ZnO Nanocomposite Film. Pharm Res 37, 178 (2020). https://doi.org/10.1007/s11095-020-02910-z

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