Abstract
In the estimation of immunobiochemical indices and the use of formalized statistics, clinical models of ischemic and hemorrhagic strokes aggravated by metabolic syndrome and of diffuse liver diseases have demonstrated the formation (under the influence of metabolic syndrome) of a reaction that is qualitatively homogeneous and quantitatively more pronounced with hemorrhagic stroke in the form of an imbalance in the primary and secondary products of free radical oxidation of lipids and proteins; the preferential activation of enzymatic and nonenzymatic mechanisms of the antioxidant system against a background of an accumulation of proinflammatory cytokines, and, in patients with diffuse liver diseases, the presence of a universal mechanism of the association of the intensity of oxidative stress (free radical oxidation) with the development of cytolytic syndrome, disorders of lipid metabolism, immune status, and the initiation of apoptosis mechanisms.
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This work was performed as a part of the program of planned research work at the Burdenko Voronezh State Medical University and in Vishnevsky National Medical Research Center of Surgery, Moscow.
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Statement of compliance with standards of research involving humans as subjects. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research ethics committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Participants permission and informed consent were not required, since the patients were examined in terms of medical care provided by the Ministry of Health of Russia during hospital treatment.
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Translated by A. Barkhash
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Zemskov, A.M., Zemskov, V.M., Luzky, M.A. et al. Immunometabolic Associations in Diseases of Complex Genesis. Biol Bull Rev 10, 280–284 (2020). https://doi.org/10.1134/S2079086420040118
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DOI: https://doi.org/10.1134/S2079086420040118