Abstract
Cervical dystonia is associated with neck pain in a significant proportion of cases, but the mechanisms underlying pain are largely unknown. In this exploratory study, we compared demographic and clinical variables in cervical dystonia patients with and without neck pain from the Italian Dystonia Registry. Univariable and multivariable logistic regression analysis indicated a higher frequency of sensory trick and a lower educational level among patients with pain.
This is a preview of subscription content, log in via an institution to check access.
Change history
20 October 2020
The original version of this article unfortunately contained a mistake.
References
Albanese A, Bhatia K, Bressman SB, DeLong MR, Fahn S, Fung VSC, Hallett M et al (2013) Phenomenology and classification of dystonia: a consensus update. Mov Disord 28(7):863–873
Aniello MS, Martino D, Masi G, Livrea P, Defazio G (2006) Sensitivity and specificity of a self-administered questionnaire for familial screening of adult-onset dystonia. Mov Disord 21(4):571–575
Avenali M, De Icco R, Tinazzi M, Defazio G, Tronconi L, Sandrini G, Tassorelli C (2018) Pain in focal dystonias—a focused review to address an important component of the disease. Parkinsonism Relat Disord 54:17–24
Baarbé JK, Yielder P, Haavik H, Holmes MWR, Murphy BA (2018) Subclinical recurrent neck pain and its treatment impacts motor training-induced plasticity of the cerebellum and motor cortex. PLoS ONE 13(2):e0193413
Blackie JD, Lees AJ (1990) Botulinum toxin treatment in spasmodic torticollis. J Neurol Neurosurg Psychiatry 53(8):640–643
Brugger F, Peters A, Georgiev D, Kägi G, Balint B, Bhatia K, Day BL (2019) Sensory trick efficacy in cervical dystonia is linked to processing of neck proprioception. Parkinsonism Relat Disord 61:50–56
Castagna A, Albanese A (2019) Management of cervical dystonia with botulinum neurotoxins and EMG/ultrasound guidance. Neurol Clin Pract 9(1):64–73
Charles PD, Adler CH, Stacy M, Comella C, Jankovic J, Adams AM, Schwartz M, Brin MF (2014) Cervical dystonia and pain: characteristics and treatment patterns from CD PROBE (Cervical Dystonia Patient Registry for Observation of OnabotulinumtoxinA Efficacy). J Neurol 261(7):1309–1319
Conte A, Defazio G, Hallett M, Fabbrini G, Berardelli A (2019) The role of sensory information in the pathophysiology of focal dystonias. Nat Rev Neurol 15:224–233
Coombes SA, Misra G (2016) Pain and motor processing in the human cerebellum. Pain 157(1):117–127
Defazio G, Esposito M, Abbruzzese G, Scaglione CL, Fabbrini G, Ferrazzano G, Peluso S et al (2017) The Italian dystonia registry: rationale, design and preliminary findings. Neurol Sci 38(5):819–825
Defazio G, Fabbrini G, Erro R, Albanese A, Barone P, Zibetti M, Esposito M et al (2020) Does acute peripheral trauma contribute to idiopathic adult-onset dystonia? Parkinsonism Relat Disord 71:40–43
Hosmer DW, Lemeshow S (1989) Applied logistic regression. Wiley, Hoboken
Kim W, Kim SK, Nabekura J (2017) Functional and structural plasticity in the primary somatosensory cortex associated with chronic pain. J Neurochem 141(4):499–506
Kulisevsky J, Lleo A, Gironell A, Molet J, Pascual-Sedano B, Pares P (2000) Bilateral pallidal stimulation for cervical dystonia: dissociated pain and motor improvement. Neurology 55(11):1754–1755
Marttinen MK, Kautiainen H, Haanpää M, Pohjankoski H, Vuorimaa H, Hintikka J, Kauppi MJ (2019) Pain-related factors in older adults. Scand J Pain 19(4):797–803
Naumann M, Magyar-Lehmann S, Reiners K, Erbguth F, Leenders KL (2000) Sensory tricks in cervical dystonia: perceptual dysbalance of parietal cortex modulates frontal motor programming. Ann Neurol 47(3):322–328
Ramos VFML, Karp BI, Hallett M (2014) Tricks in dystonia: ordering the complexity. J Neurol Neurosurg Psychiatry 85(9):987–993
Tinazzi M, Squintani GM, Bhatia K, Segatti A, Donato F, Valeriani M, Erro R (2019) Pain in cervical dystonia: evidence of abnormal inhibitory control. Parkinsonism Relat Disord 65:252–255
Funding
This research did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors. Roberto Erro: Speaking honoraria from Bial; Travel grants from the International Parkinson’s Disease and Movement Disorder Society, and the American Academy of Neurology; Royalties for the book Case Series in Movement Disorders—Common and Uncommon Presentations, Cambridge University Press, 2017; member of the editorial board of Movement Disorders, Parkinsonism and Related Disorders, Nature Parkinson’s Disease Journal. Francesca Morgante: Speaking honoraria from Abbvie, Medtronic, Zambon, Bial, Merz; Travel grants from the International Parkinson’s Disease and Movement Disorder Society; Advisory board fees from Merz; Consultancies fees from Merz and Bial; Research support from Boston Scientific, Merz, and Global Kynetic; Royalties for the book Disorders of Movement, Springer Verlag; member of the editorial board of Movement Disorders, Movement Disorders Clinical Practice, European Journal of Neurology.
Author information
Authors and Affiliations
Contributions
MT and GD conceived the study, performed the analysis, and reviewed the manuscript. MT and RE wrote the first draft. All other authors contributed to data collection and reviewed the manuscript.
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest related to the current work.
Ethical approval
This study was approved by the local Ethics Committee and was performed according to the Declaration of Helsinki. We also confirm that we have read the Journal’s position on issues involved in ethical publication and affirm that this work is consistent with those guidelines.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Tinazzi, M., Erro, R., Mascia, M.M. et al. Demographic and clinical determinants of neck pain in idiopathic cervical dystonia. J Neural Transm 127, 1435–1439 (2020). https://doi.org/10.1007/s00702-020-02245-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00702-020-02245-4