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CYTOTOXICITY

NKG7 makes a better killer

Nature Immunology volume 21, pages 1139–1140 (2020)Cite this article

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New studies suggest that NKG7 is essential for NK and CD8+ T cell cytotoxic degranulation and CD4+ T cell activation and proinflammatory responses. While the mechanism is yet to be determined, the functional relevance is exciting and opens the possibility of a new target for cellular immunotherapies.

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Fig. 1: NKG7 is required to mediate cellular cytotoxicity and the production of inflammatory factors in T and NK cells.

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Authors and Affiliations

  1. Laboratory of Molecular Immunology and Immunotherapy, Blood Research Institute, Versiti, Milwaukee, WI, USA

    Subramaniam Malarkannan

  2. Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI, USA

    Subramaniam Malarkannan

  3. Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA

    Subramaniam Malarkannan

  4. Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA

    Subramaniam Malarkannan

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  1. Subramaniam Malarkannan
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Correspondence to Subramaniam Malarkannan.

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Malarkannan, S. NKG7 makes a better killer. Nat Immunol 21, 1139–1140 (2020). https://doi.org/10.1038/s41590-020-0767-5

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