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Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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FAPP2 Accelerates the Proliferation and Invasion of Hepatocellular Carcinoma Cells via Wnt/β-Catenin Signaling

Volume 39, Issue 4, 2020, pp. 309-316
DOI: 10.1615/JEnvironPatholToxicolOncol.2020035441
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ABSTRACT

Four-phosphate adaptor-2 (FAPP2) has been recently identified as a tumor-associated regulator that is closely related to tumorigenesis. However, the precise role of FAPP2 in hepatocellular carcinoma (HCC) is still largely unknown. This study was designed to determine the function and molecular mechanisms of FAPP2 in HCC. Elevated expression of FAPP2 commonly occurred in the tumor tissue of HCC compared with normal controls. High expression of FAPP2 was also detected in HCC cell lines, and its knockdown markedly decreased the proliferation, colony formation, and invasion of HCC cells. Upregulation of FAPP2 using a FAPP2 expression vector markedly promoted the proliferation colony formation and invasion of HCC cells. FAPP2 was found to promote the activation of Wnt/β-catenin signaling. Importantly, inhibition of Wnt/β-catenin signaling abrogated the FAPP2 overexpression-conferred oncogenic effect in HCC cells. In addition, xenograft tumor experiments revealed that knockdown of FAPP2 significantly decreased the tumorigenicity of HCC cells in vivo. Taken together, our data reveal a tumor-promotion function of FAPP2 in HCC and demonstrate that knockdown of FAPP2 is capable of suppressing HCC cell proliferation and invasion through downregulation of Wnt/β-catenin signaling. FAPP2 may be an attractive candidate anticancer target for HCC.

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CITED BY
  1. Lee Jiyeon, Hwang Ji-Hyun, Chun Harim, Woo Wonjin, Oh Sekyung, Choi Jungmin, Kim Lark Kyun, PLEKHA8P1 Promotes Tumor Progression and Indicates Poor Prognosis of Liver Cancer, International Journal of Molecular Sciences, 22, 14, 2021. Crossref

  2. Yuan Tian, Wang Jinhuan, Shi Ce, Wang Yi, Xia Bing, Xu Wen, Yang Hongliang, Yang Yaling, Ye Matthew T., Khalid Samah, Liang Yong, Tian Chen, You M. James, Wang Yafei, Downregulation of FAPP2 gene induces cell autophagy and inhibits PI3K/AKT/mTOR pathway in T‐cell acute lymphoblastic leukemia , Hematological Oncology, 40, 2, 2022. Crossref

  3. Nagaraj Meghana, Höring Marcus, Ahonen Maria A., Nguyen Van Dien, Zhou You, Vihinen Helena, Jokitalo Eija, Liebisch Gerhard, Nidhina Haridas P.A., Olkkonen Vesa M., GOLM1 depletion modifies cellular sphingolipid metabolism and adversely affects cell growth, Journal of Lipid Research, 63, 9, 2022. Crossref

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